Matches in SemOpenAlex for { <https://semopenalex.org/work/W2534410903> ?p ?o ?g. }
- W2534410903 endingPage "3685" @default.
- W2534410903 startingPage "3674" @default.
- W2534410903 abstract "Harnessing epigenetic regulation is crucial for the efficient and proper differentiation of pluripotent stem cells (PSCs) into desired cell types. Histone H3 lysine 27 trimethylation (H3K27me3) functions as a barrier against cell differentiation through the suppression of developmental gene expression in PSCs. Here, we have generated human PSC (hPSC) lines in which genome-wide reduction of H3K27me3 can be induced by ectopic expression of the catalytic domain of the histone demethylase JMJD3 (called JMJD3c). We found that transient, forced demethylation of H3K27me3 alone triggers the upregulation of mesoendodermal genes, even when the culture conditions for the hPSCs are not changed. Furthermore, transient and forced expression of JMJD3c followed by the forced expression of lineage-defining transcription factors enabled the hPSCs to activate tissue-specific genes directly. We have also shown that the introduction of JMJD3c facilitates the differentiation of hPSCs into functional hepatic cells and skeletal muscle cells. These results suggest the utility of the direct manipulation of epigenomes for generating desired cell types from hPSCs for cell transplantation therapy and platforms for drug screenings." @default.
- W2534410903 created "2016-10-28" @default.
- W2534410903 creator A5004419482 @default.
- W2534410903 creator A5005105498 @default.
- W2534410903 creator A5015193562 @default.
- W2534410903 creator A5021252599 @default.
- W2534410903 creator A5027256048 @default.
- W2534410903 creator A5053106370 @default.
- W2534410903 creator A5054450573 @default.
- W2534410903 creator A5058044738 @default.
- W2534410903 creator A5059312822 @default.
- W2534410903 creator A5085390231 @default.
- W2534410903 creator A5090988113 @default.
- W2534410903 date "2016-10-15" @default.
- W2534410903 modified "2023-10-11" @default.
- W2534410903 title "Transient ectopic expression of the histone demethylase JMJD3 accelerates the differentiation of human pluripotent stem cells" @default.
- W2534410903 cites W1888129961 @default.
- W2534410903 cites W1965868708 @default.
- W2534410903 cites W1968931043 @default.
- W2534410903 cites W1974069185 @default.
- W2534410903 cites W1982882278 @default.
- W2534410903 cites W1985342348 @default.
- W2534410903 cites W1987182199 @default.
- W2534410903 cites W1990897270 @default.
- W2534410903 cites W1996362127 @default.
- W2534410903 cites W1998071003 @default.
- W2534410903 cites W2000961563 @default.
- W2534410903 cites W2001858515 @default.
- W2534410903 cites W2003140132 @default.
- W2534410903 cites W2006604617 @default.
- W2534410903 cites W2007227967 @default.
- W2534410903 cites W2007585921 @default.
- W2534410903 cites W2008735740 @default.
- W2534410903 cites W2011181841 @default.
- W2534410903 cites W2015701192 @default.
- W2534410903 cites W2016534953 @default.
- W2534410903 cites W2017840637 @default.
- W2534410903 cites W2018905452 @default.
- W2534410903 cites W2019229253 @default.
- W2534410903 cites W2022140142 @default.
- W2534410903 cites W2024334977 @default.
- W2534410903 cites W2030523067 @default.
- W2534410903 cites W2034882046 @default.
- W2534410903 cites W2040909468 @default.
- W2534410903 cites W2048107295 @default.
- W2534410903 cites W2049598074 @default.
- W2534410903 cites W2049991359 @default.
- W2534410903 cites W2051553283 @default.
- W2534410903 cites W2053328538 @default.
- W2534410903 cites W2053739797 @default.
- W2534410903 cites W2059241371 @default.
- W2534410903 cites W2067563155 @default.
- W2534410903 cites W2074283287 @default.
- W2534410903 cites W2082430940 @default.
- W2534410903 cites W2083441653 @default.
- W2534410903 cites W2086943348 @default.
- W2534410903 cites W2088170764 @default.
- W2534410903 cites W2092445212 @default.
- W2534410903 cites W2096011465 @default.
- W2534410903 cites W2096083625 @default.
- W2534410903 cites W2098597036 @default.
- W2534410903 cites W2101912958 @default.
- W2534410903 cites W2102074241 @default.
- W2534410903 cites W2104490470 @default.
- W2534410903 cites W2107575419 @default.
- W2534410903 cites W2109020750 @default.
- W2534410903 cites W2115042993 @default.
- W2534410903 cites W2116318886 @default.
- W2534410903 cites W2120060263 @default.
- W2534410903 cites W2122674384 @default.
- W2534410903 cites W2123773614 @default.
- W2534410903 cites W2127314696 @default.
- W2534410903 cites W2129924706 @default.
- W2534410903 cites W2131635560 @default.
- W2534410903 cites W2133452708 @default.
- W2534410903 cites W2133536768 @default.
- W2534410903 cites W2134087142 @default.
- W2534410903 cites W2138977668 @default.
- W2534410903 cites W2142046859 @default.
- W2534410903 cites W2143261086 @default.
- W2534410903 cites W2143764351 @default.
- W2534410903 cites W2152426454 @default.
- W2534410903 cites W2153424791 @default.
- W2534410903 cites W2154138399 @default.
- W2534410903 cites W2157232603 @default.
- W2534410903 cites W2158610627 @default.
- W2534410903 cites W2166628699 @default.
- W2534410903 cites W2168967248 @default.
- W2534410903 cites W2170551349 @default.
- W2534410903 cites W2191128990 @default.
- W2534410903 cites W2280655495 @default.
- W2534410903 cites W2320983896 @default.
- W2534410903 cites W2739174192 @default.
- W2534410903 doi "https://doi.org/10.1242/dev.139360" @default.
- W2534410903 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5087640" @default.
- W2534410903 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27802135" @default.
- W2534410903 hasPublicationYear "2016" @default.
- W2534410903 type Work @default.