Matches in SemOpenAlex for { <https://semopenalex.org/work/W253443366> ?p ?o ?g. }
- W253443366 endingPage "28" @default.
- W253443366 startingPage "313" @default.
- W253443366 abstract "Evidence suggests that neutrophils are important in host defenses against invasive aspergillosis and mucormycosis, although hyphae in these lesions are too large to be phagocytized. Interactions of neutrophils with hyphae of Aspergillus fumigatus and Rhizopus oryzae were studed in vitro. Light and electron microscopic observations indicated that neutrophils attached to and spread over the surfaces of hyphae, even in the absence of serum. This was followed by dramatic morphologic changes which suggested severe damage and probably death of hyphae. An assay of neutrophil-induced reduction of uptake of radioisotopes was used to quantitate damage to the fungi by neutrophils from normal subjects. Damage to hyphae was inhibited by a variety of compounds which are known to affect neutrophil surface functions, motility, and metabolism. Use of inhibitors of oxidative microbicidal mechanisms of neutrophils indicated the central importance of these mechanisms in damage to hyphae. Inhibitors of neutrophil cationic proteins altered damage only to Rhizopus. Damage to hyphae by lysozyme suggested that it may play a secondary role in the neutrophil, primarily against Aspergillus. This new nonphagocytic mechanism may play an important role in host defenses against these and other hyphal forms of fungi." @default.
- W253443366 created "2016-06-24" @default.
- W253443366 creator A5060463238 @default.
- W253443366 creator A5073259822 @default.
- W253443366 creator A5078618033 @default.
- W253443366 creator A5083977208 @default.
- W253443366 date "1978-05-01" @default.
- W253443366 modified "2023-10-12" @default.
- W253443366 title "Damage to hyphal forms of fungi by human leukocytes in vitro. A possible host defense mechanism in aspergillosis and mucormycosis." @default.
- W253443366 cites W123024795 @default.
- W253443366 cites W1449964103 @default.
- W253443366 cites W1546679115 @default.
- W253443366 cites W1561780216 @default.
- W253443366 cites W1929503553 @default.
- W253443366 cites W1969158315 @default.
- W253443366 cites W1970480024 @default.
- W253443366 cites W1972824411 @default.
- W253443366 cites W1976325235 @default.
- W253443366 cites W1978498634 @default.
- W253443366 cites W1991236622 @default.
- W253443366 cites W1996152805 @default.
- W253443366 cites W2024064492 @default.
- W253443366 cites W2025804022 @default.
- W253443366 cites W2029090265 @default.
- W253443366 cites W2030764175 @default.
- W253443366 cites W2036361338 @default.
- W253443366 cites W2047202043 @default.
- W253443366 cites W2047953635 @default.
- W253443366 cites W2049059366 @default.
- W253443366 cites W2049291162 @default.
- W253443366 cites W2068350209 @default.
- W253443366 cites W2073635661 @default.
- W253443366 cites W2080883399 @default.
- W253443366 cites W2082076412 @default.
- W253443366 cites W2090879136 @default.
- W253443366 cites W2095029703 @default.
- W253443366 cites W2095139195 @default.
- W253443366 cites W2165271448 @default.
- W253443366 cites W2182038113 @default.
- W253443366 cites W2271741392 @default.
- W253443366 cites W2346629900 @default.
- W253443366 cites W4290155823 @default.
- W253443366 cites W63490885 @default.
- W253443366 cites W81032753 @default.
- W253443366 cites W87082738 @default.
- W253443366 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2018207" @default.
- W253443366 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/347942" @default.
- W253443366 hasPublicationYear "1978" @default.
- W253443366 type Work @default.
- W253443366 sameAs 253443366 @default.
- W253443366 citedByCount "89" @default.
- W253443366 countsByYear W2534433662013 @default.
- W253443366 countsByYear W2534433662015 @default.
- W253443366 countsByYear W2534433662016 @default.
- W253443366 countsByYear W2534433662017 @default.
- W253443366 countsByYear W2534433662018 @default.
- W253443366 countsByYear W2534433662019 @default.
- W253443366 countsByYear W2534433662021 @default.
- W253443366 countsByYear W2534433662022 @default.
- W253443366 crossrefType "journal-article" @default.
- W253443366 hasAuthorship W253443366A5060463238 @default.
- W253443366 hasAuthorship W253443366A5073259822 @default.
- W253443366 hasAuthorship W253443366A5078618033 @default.
- W253443366 hasAuthorship W253443366A5083977208 @default.
- W253443366 hasConcept C100544194 @default.
- W253443366 hasConcept C170493617 @default.
- W253443366 hasConcept C202751555 @default.
- W253443366 hasConcept C203014093 @default.
- W253443366 hasConcept C2776391196 @default.
- W253443366 hasConcept C2777983669 @default.
- W253443366 hasConcept C2778541762 @default.
- W253443366 hasConcept C2778753027 @default.
- W253443366 hasConcept C2779787849 @default.
- W253443366 hasConcept C54166955 @default.
- W253443366 hasConcept C55493867 @default.
- W253443366 hasConcept C86803240 @default.
- W253443366 hasConcept C89423630 @default.
- W253443366 hasConcept C90080823 @default.
- W253443366 hasConceptScore W253443366C100544194 @default.
- W253443366 hasConceptScore W253443366C170493617 @default.
- W253443366 hasConceptScore W253443366C202751555 @default.
- W253443366 hasConceptScore W253443366C203014093 @default.
- W253443366 hasConceptScore W253443366C2776391196 @default.
- W253443366 hasConceptScore W253443366C2777983669 @default.
- W253443366 hasConceptScore W253443366C2778541762 @default.
- W253443366 hasConceptScore W253443366C2778753027 @default.
- W253443366 hasConceptScore W253443366C2779787849 @default.
- W253443366 hasConceptScore W253443366C54166955 @default.
- W253443366 hasConceptScore W253443366C55493867 @default.
- W253443366 hasConceptScore W253443366C86803240 @default.
- W253443366 hasConceptScore W253443366C89423630 @default.
- W253443366 hasConceptScore W253443366C90080823 @default.
- W253443366 hasIssue "2" @default.
- W253443366 hasLocation W2534433661 @default.
- W253443366 hasOpenAccess W253443366 @default.
- W253443366 hasPrimaryLocation W2534433661 @default.
- W253443366 hasRelatedWork W1916951787 @default.
- W253443366 hasRelatedWork W2078799369 @default.