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• W2534442133 endingPage "e0164396" @default.
• W2534442133 startingPage "e0164396" @default.
• W2534442133 abstract "In the practical farming of Litopenaeus vannamei, the intensive culture system and environmental pollution usually results in a high concentration of ammonia, which usually brings large detrimental effects to shrimp, such as increasing the susceptibility to pathogens, reducing growth, decreasing osmoregulatory capacity, increasing the molting frequency, and even causing high mortality. However, little information is available on the molecular mechanisms of the detrimental effects of ammonia stress in shrimp. In this study, we performed comparative transcriptome analysis between ammonia-challenged and control groups from the same family of L. vannamei to identify the key genes and pathways response to ammonia stress. The comparative transcriptome analysis identified 136 significantly differentially expressed genes that have high homologies with the known proteins in aquatic species, among which 94 genes are reported potentially related to immune function, and the rest of the genes are involved in apoptosis, growth, molting, and osmoregulation. Fourteen GO terms and 6 KEGG pathways were identified to be significantly changed by ammonia stress. In these GO terms, 13 genes have been studied in aquatic species, and 11 of them were reported potentially involved in immune defense and two genes were related to molting. In the significantly changed KEGG pathways, all the 7 significantly changed genes have been reported in shrimp, and four of them were potentially involved in immune defense and the other three were related to molting, defending toxicity, and osmoregulation, respectively. In addition, majority of the significantly changed genes involved in nitrogen metabolisms that play an important role in reducing ammonia toxicity failed to perform the protection function. The present results have supplied molecular level support for the previous founding of the detrimental effects of ammonia stress in shrimp, which is a prerequisite for better understanding the molecular mechanism of the immunosuppression from ammonia stress." @default.
• W2534442133 created "2016-10-28" @default.
• W2534442133 creator A5027224776 @default.
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• W2534442133 date "2016-10-19" @default.
• W2534442133 modified "2023-10-12" @default.
• W2534442133 title "Transcriptome Analysis of the Hepatopancreas in the Pacific White Shrimp (Litopenaeus vannamei) under Acute Ammonia Stress" @default.
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• W2534442133 doi "https://doi.org/10.1371/journal.pone.0164396" @default.
• W2534442133 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5070816" @default.
• W2534442133 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27760162" @default.
• W2534442133 hasPublicationYear "2016" @default.
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