FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2534448389> ?p ?o ?g. }

• W2534448389 endingPage "24" @default.
• W2534448389 startingPage "14" @default.
• W2534448389 abstract "The organic anion-transporting polypeptides represent an important family of drug uptake transporters that mediate the cellular uptake of a broad range of substrates including numerous drugs. Doxorubicin is a highly efficacious and well-established anthracycline chemotherapeutic agent commonly used in the treatment of a wide range of cancers. Although doxorubicin is a known substrate for efflux transporters such as P-glycoprotein (P-gp; MDR1, ABCB1), significantly less is known regarding its interactions with drug uptake transporters. Here, we investigated the role of organic anion transporting polypeptide (OATP) transporters to the disposition of doxorubicin. A recombinant vaccinia-based method for expressing uptake transporters in HeLa cells revealed that OATP1A2, but not OATP1B1 or OATP1B3, and the rat ortholog Oatp1a4 were capable of significant doxorubicin uptake. Interestingly, transwell assays using Madin-Darby canine kidney II cell line cells stably expressing specific uptake and/or efflux transporters revealed that OATP1B1, OATP1B3, and OATP1A2, either alone or in combination with MDR1, significantly transported doxorubicin. An assessment of polymorphisms in SLCO1A2 revealed that four variants were associated with significantly impaired doxorubicin transport in vitro. In vivo doxorubicin disposition studies revealed that doxorubicin plasma area under the curve was significantly higher (1.7-fold) in Slco1a/1b-/- versus wild-type mice. The liver-to-plasma ratio of doxorubicin was significantly decreased (2.3-fold) in Slco1a/1b2-/- mice and clearance was reduced by 40% compared with wild-type mice, suggesting Oatp1b transporters are important for doxorubicin hepatic uptake. In conclusion, we demonstrate important roles for OATP1A/1B in transporter-mediated uptake and disposition of doxorubicin." @default.
• W2534448389 created "2016-10-28" @default.
• W2534448389 creator A5000386786 @default.
• W2534448389 creator A5007321180 @default.
• W2534448389 creator A5054355836 @default.
• W2534448389 creator A5077772649 @default.
• W2534448389 date "2016-10-24" @default.
• W2534448389 modified "2023-10-14" @default.
• W2534448389 title "Contribution of Organic Anion-Transporting Polypeptides 1A/1B to Doxorubicin Uptake and Clearance" @default.
• W2534448389 cites W1788032165 @default.
• W2534448389 cites W1811714417 @default.
• W2534448389 cites W1882050418 @default.
• W2534448389 cites W1963760050 @default.
• W2534448389 cites W1971901938 @default.
• W2534448389 cites W1978521624 @default.
• W2534448389 cites W1984939312 @default.
• W2534448389 cites W1989818377 @default.
• W2534448389 cites W1989859921 @default.
• W2534448389 cites W1994088225 @default.
• W2534448389 cites W1997601514 @default.
• W2534448389 cites W1998275215 @default.
• W2534448389 cites W1999468683 @default.
• W2534448389 cites W2000478673 @default.
• W2534448389 cites W2005914550 @default.
• W2534448389 cites W2007811800 @default.
• W2534448389 cites W2008215698 @default.
• W2534448389 cites W2008388668 @default.
• W2534448389 cites W2010183849 @default.
• W2534448389 cites W2015755153 @default.
• W2534448389 cites W2017094452 @default.
• W2534448389 cites W2031595392 @default.
• W2534448389 cites W2034412102 @default.
• W2534448389 cites W2036726324 @default.
• W2534448389 cites W2037621239 @default.
• W2534448389 cites W2045917526 @default.
• W2534448389 cites W2046507147 @default.
• W2534448389 cites W2061222476 @default.
• W2534448389 cites W2072235727 @default.
• W2534448389 cites W2076194172 @default.
• W2534448389 cites W2076385318 @default.
• W2534448389 cites W2080359861 @default.
• W2534448389 cites W2083116825 @default.
• W2534448389 cites W2091234451 @default.
• W2534448389 cites W2095993519 @default.
• W2534448389 cites W2106535916 @default.
• W2534448389 cites W2108686166 @default.
• W2534448389 cites W2118594097 @default.
• W2534448389 cites W2122443477 @default.
• W2534448389 cites W2124077732 @default.
• W2534448389 cites W2125562614 @default.
• W2534448389 cites W2131403498 @default.
• W2534448389 cites W2134309909 @default.
• W2534448389 cites W2144134201 @default.
• W2534448389 cites W2146259511 @default.
• W2534448389 cites W2146553113 @default.
• W2534448389 cites W2146553120 @default.
• W2534448389 cites W2158604980 @default.
• W2534448389 cites W2167450468 @default.
• W2534448389 cites W3144870107 @default.
• W2534448389 doi "https://doi.org/10.1124/mol.116.105544" @default.
• W2534448389 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5198512" @default.
• W2534448389 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27777271" @default.
• W2534448389 hasPublicationYear "2016" @default.
• W2534448389 type Work @default.
• W2534448389 sameAs 2534448389 @default.
• W2534448389 citedByCount "28" @default.
• W2534448389 countsByYear W25344483892018 @default.
• W2534448389 countsByYear W25344483892019 @default.
• W2534448389 countsByYear W25344483892020 @default.
• W2534448389 countsByYear W25344483892021 @default.
• W2534448389 countsByYear W25344483892022 @default.
• W2534448389 countsByYear W25344483892023 @default.
• W2534448389 crossrefType "journal-article" @default.
• W2534448389 hasAuthorship W2534448389A5000386786 @default.
• W2534448389 hasAuthorship W2534448389A5007321180 @default.
• W2534448389 hasAuthorship W2534448389A5054355836 @default.
• W2534448389 hasAuthorship W2534448389A5077772649 @default.
• W2534448389 hasBestOaLocation W25344483891 @default.
• W2534448389 hasConcept C104317684 @default.
• W2534448389 hasConcept C112705442 @default.
• W2534448389 hasConcept C121608353 @default.
• W2534448389 hasConcept C123584848 @default.
• W2534448389 hasConcept C133936738 @default.
• W2534448389 hasConcept C149011108 @default.
• W2534448389 hasConcept C150903083 @default.
• W2534448389 hasConcept C185592680 @default.
• W2534448389 hasConcept C189613389 @default.
• W2534448389 hasConcept C200082930 @default.
• W2534448389 hasConcept C202751555 @default.
• W2534448389 hasConcept C207001950 @default.
• W2534448389 hasConcept C2776678969 @default.
• W2534448389 hasConcept C2776694085 @default.
• W2534448389 hasConcept C2776802502 @default.
• W2534448389 hasConcept C2777366897 @default.
• W2534448389 hasConcept C2778707650 @default.
• W2534448389 hasConcept C2781303535 @default.
• W2534448389 hasConcept C501593827 @default.
• W2534448389 hasConcept C530470458 @default.

• next