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• W2534462074 abstract "Aquaporins (AQPs) are membrane water/glyc- erol channels that are involved in many physiological processes. Their primary function is to facilitate the bidi- rectional transfer of water and small solutes across biological membranes in response to osmotic gradients. Aquaglyceroporins, a subset of the AQP family, are the only mammalian proteins with the ability to permeate glycerol. For a long time, AQP7 has been the only aqua- glyceroporin associated with the adipose tissue, which is the major source of circulating glycerol in response to the energy demand. AQP7 dysregulation was positively cor- related with obesity onset and adipocyte glycerol permeation through AQP7 was appointed as a novel reg- ulator of adipocyte metabolism and whole-body fat mass. Recently, AQP3, AQP9, AQP10 and AQP11 were addi- tionally identified in human adipocytes and proposed as additional glycerol pathways in these cells. This review contextualizes the importance of aquaglyceroporins in adipose tissue biology and highlights aquaglyceroporins' unique structural features which are relevant for the design of effective therapeutic compounds. We also refer to the latest advances in the identification and characterization of novel aquaporin isoforms in adipose tissue. Finally, considerations on the actual progress of aquaporin research and its implications on obesity therapy are suggested." @default.
• W2534462074 created "2016-10-28" @default.
• W2534462074 creator A5046354438 @default.
• W2534462074 date "2015-01-01" @default.
• W2534462074 modified "2023-09-24" @default.
• W2534462074 title "Aquaglyceroporins: implications in adipose biology and obesity" @default.
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