Matches in SemOpenAlex for { <https://semopenalex.org/work/W253447517> ?p ?o ?g. }
Showing items 1 to 67 of
67
with 100 items per page.
- W253447517 abstract "Cell migration is one of the most intriguing areas in cell biology and has attracted many interdisciplinary studies. It is regulated by complex biochemical signaling networks and comprises many mechanical processes, including protrusion, adhesion, translocation of the cell body and retraction of the rear. This dissertation starts with the signaling pathway that senses external chemoattractant, specifically, the Ras pathway (Chapter 2). We found that the response of an activated Ras shows near perfect adaptation. We attempted to fit the results using mathematical models for the two possible simple network topologies that can provide perfect adaptation. Only one, the incoherent feedforward network, is able to accurately describe the experimental results. This analysis revealed that adaptation in this Ras pathway is achieved through the proportional activation of upstream components and not through negative feedback loops. From Chapter 3 to Chapter 5, we integrated chemical reactions inside the cell with the mechanical process of cell migration. In Chapter 3, we set up a framework, based on phase field method, to describe the cell shape and the chemical reactions in a moving cell. Under this framework, we developed a computational model on cell morphodynamics in Chapter 4. Our model incorporates the membrane bending force and the surface tension and enforces a constant area. Furthermore, it implements a cross linked actin filament field and an actin bundle field that are responsible for the protrusion and retraction forces, respectively. The model was successfully applied to fish keratocytes and Dictystelium cells. In Chapter 5, we studied the coupling between adhesion mechanism and actin flow in keratocytes. The adhesion mechanism incorporated both the gripping mode and the slipping mode. The model-predicted maps of actin flow, substrate stress and the alignment between the two are quantitatively consistent with experimental observations. Furthermore, we explored the phase diagram of cell migration by varying myosin II and adhesion strength. Our model suggested that the pattern of the actin flow inside the cell, the cell velocity and the cell shape are determined by the integration of actin polymerization, myosin contraction, the adhesion and membrane forces" @default.
- W253447517 created "2016-06-24" @default.
- W253447517 creator A5006772202 @default.
- W253447517 date "2011-01-01" @default.
- W253447517 modified "2023-09-26" @default.
- W253447517 title "Computational models on cell migration" @default.
- W253447517 hasPublicationYear "2011" @default.
- W253447517 type Work @default.
- W253447517 sameAs 253447517 @default.
- W253447517 citedByCount "0" @default.
- W253447517 crossrefType "journal-article" @default.
- W253447517 hasAuthorship W253447517A5006772202 @default.
- W253447517 hasConcept C119599485 @default.
- W253447517 hasConcept C125705527 @default.
- W253447517 hasConcept C127413603 @default.
- W253447517 hasConcept C137738243 @default.
- W253447517 hasConcept C1491633281 @default.
- W253447517 hasConcept C151166631 @default.
- W253447517 hasConcept C184720557 @default.
- W253447517 hasConcept C185592680 @default.
- W253447517 hasConcept C186060115 @default.
- W253447517 hasConcept C41008148 @default.
- W253447517 hasConcept C54355233 @default.
- W253447517 hasConcept C62478195 @default.
- W253447517 hasConcept C86803240 @default.
- W253447517 hasConcept C95444343 @default.
- W253447517 hasConceptScore W253447517C119599485 @default.
- W253447517 hasConceptScore W253447517C125705527 @default.
- W253447517 hasConceptScore W253447517C127413603 @default.
- W253447517 hasConceptScore W253447517C137738243 @default.
- W253447517 hasConceptScore W253447517C1491633281 @default.
- W253447517 hasConceptScore W253447517C151166631 @default.
- W253447517 hasConceptScore W253447517C184720557 @default.
- W253447517 hasConceptScore W253447517C185592680 @default.
- W253447517 hasConceptScore W253447517C186060115 @default.
- W253447517 hasConceptScore W253447517C41008148 @default.
- W253447517 hasConceptScore W253447517C54355233 @default.
- W253447517 hasConceptScore W253447517C62478195 @default.
- W253447517 hasConceptScore W253447517C86803240 @default.
- W253447517 hasConceptScore W253447517C95444343 @default.
- W253447517 hasLocation W2534475171 @default.
- W253447517 hasOpenAccess W253447517 @default.
- W253447517 hasPrimaryLocation W2534475171 @default.
- W253447517 hasRelatedWork W1985764672 @default.
- W253447517 hasRelatedWork W1999199566 @default.
- W253447517 hasRelatedWork W1999418944 @default.
- W253447517 hasRelatedWork W2046754542 @default.
- W253447517 hasRelatedWork W2051113230 @default.
- W253447517 hasRelatedWork W2051142201 @default.
- W253447517 hasRelatedWork W2056498968 @default.
- W253447517 hasRelatedWork W2059814482 @default.
- W253447517 hasRelatedWork W2068755239 @default.
- W253447517 hasRelatedWork W2073615040 @default.
- W253447517 hasRelatedWork W2083694798 @default.
- W253447517 hasRelatedWork W2145699930 @default.
- W253447517 hasRelatedWork W2608882818 @default.
- W253447517 hasRelatedWork W2769730059 @default.
- W253447517 hasRelatedWork W2795839379 @default.
- W253447517 hasRelatedWork W2920064491 @default.
- W253447517 hasRelatedWork W2991159269 @default.
- W253447517 hasRelatedWork W2999677295 @default.
- W253447517 hasRelatedWork W3008246820 @default.
- W253447517 hasRelatedWork W2740568878 @default.
- W253447517 isParatext "false" @default.
- W253447517 isRetracted "false" @default.
- W253447517 magId "253447517" @default.
- W253447517 workType "article" @default.