FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2534494590> ?p ?o ?g. }

• W2534494590 abstract "Combining genome-wide structural models with phenomenological data is at the forefront of efforts to understand the organizational principles regulating the human genome. Here, we use chromosome-chromosome contact data as knowledge-based constraints for large-scale three-dimensional models of the human diploid genome. The resulting models remain minimally entangled and acquire several functional features that are observed in vivo and that were never used as input for the model. We find, for instance, that gene-rich, active regions are drawn towards the nuclear center, while gene poor and lamina-associated domains are pushed to the periphery. These and other properties persist upon adding local contact constraints, suggesting their compatibility with non-local constraints for the genome organization. The results show that suitable combinations of data analysis and physical modelling can expose the unexpectedly rich functionally-related properties implicit in chromosome-chromosome contact data. Specific directions are suggested for further developments based on combining experimental data analysis and genomic structural modelling." @default.
• W2534494590 created "2016-10-28" @default.
• W2534494590 creator A5072856663 @default.
• W2534494590 creator A5082508483 @default.
• W2534494590 creator A5083284785 @default.
• W2534494590 creator A5083493986 @default.
• W2534494590 creator A5090755680 @default.
• W2534494590 date "2016-10-27" @default.
• W2534494590 modified "2023-10-14" @default.
• W2534494590 title "Hi-C-constrained physical models of human chromosomes recover functionally-related properties of genome organization" @default.
• W2534494590 cites W1831401007 @default.
• W2534494590 cites W1973062929 @default.
• W2534494590 cites W1982728345 @default.
• W2534494590 cites W1986986500 @default.
• W2534494590 cites W1988650678 @default.
• W2534494590 cites W1989582360 @default.
• W2534494590 cites W1991232135 @default.
• W2534494590 cites W1994536648 @default.
• W2534494590 cites W1996484660 @default.
• W2534494590 cites W2001576815 @default.
• W2534494590 cites W2004369921 @default.
• W2534494590 cites W2012042594 @default.
• W2534494590 cites W2014677321 @default.
• W2534494590 cites W2018617695 @default.
• W2534494590 cites W2018626566 @default.
• W2534494590 cites W2019465613 @default.
• W2534494590 cites W2023186182 @default.
• W2534494590 cites W2026865241 @default.
• W2534494590 cites W2030948026 @default.
• W2534494590 cites W2032816890 @default.
• W2534494590 cites W2037158103 @default.
• W2534494590 cites W2038774969 @default.
• W2534494590 cites W2052660967 @default.
• W2534494590 cites W2056482755 @default.
• W2534494590 cites W2061015334 @default.
• W2534494590 cites W2065006553 @default.
• W2534494590 cites W2065956398 @default.
• W2534494590 cites W2070021921 @default.
• W2534494590 cites W2070693812 @default.
• W2534494590 cites W2073026107 @default.
• W2534494590 cites W2073504534 @default.
• W2534494590 cites W2074915491 @default.
• W2534494590 cites W2081080458 @default.
• W2534494590 cites W2082025678 @default.
• W2534494590 cites W2084861373 @default.
• W2534494590 cites W2086575741 @default.
• W2534494590 cites W2087481015 @default.
• W2534494590 cites W2087588724 @default.
• W2534494590 cites W2089333407 @default.
• W2534494590 cites W2090037139 @default.
• W2534494590 cites W2092499706 @default.
• W2534494590 cites W2097637232 @default.
• W2534494590 cites W2097798909 @default.
• W2534494590 cites W2098497185 @default.
• W2534494590 cites W2101249563 @default.
• W2534494590 cites W2108393758 @default.
• W2534494590 cites W2108871359 @default.
• W2534494590 cites W2112785635 @default.
• W2534494590 cites W2115543920 @default.
• W2534494590 cites W2122103654 @default.
• W2534494590 cites W2137601569 @default.
• W2534494590 cites W2142270559 @default.
• W2534494590 cites W2144934389 @default.
• W2534494590 cites W2145619687 @default.
• W2534494590 cites W2150313376 @default.
• W2534494590 cites W2159479483 @default.
• W2534494590 cites W2159890732 @default.
• W2534494590 cites W2162618509 @default.
• W2534494590 cites W2170696599 @default.
• W2534494590 cites W2265509206 @default.
• W2534494590 cites W2320400318 @default.
• W2534494590 cites W2320440892 @default.
• W2534494590 cites W2323056845 @default.
• W2534494590 cites W2335284814 @default.
• W2534494590 cites W2401568148 @default.
• W2534494590 cites W2470258573 @default.
• W2534494590 doi "https://doi.org/10.1038/srep35985" @default.
• W2534494590 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5081523" @default.
• W2534494590 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27786255" @default.
• W2534494590 hasPublicationYear "2016" @default.
• W2534494590 type Work @default.
• W2534494590 sameAs 2534494590 @default.
• W2534494590 citedByCount "70" @default.
• W2534494590 countsByYear W25344945902017 @default.
• W2534494590 countsByYear W25344945902018 @default.
• W2534494590 countsByYear W25344945902019 @default.
• W2534494590 countsByYear W25344945902020 @default.
• W2534494590 countsByYear W25344945902021 @default.
• W2534494590 countsByYear W25344945902022 @default.
• W2534494590 countsByYear W25344945902023 @default.
• W2534494590 crossrefType "journal-article" @default.
• W2534494590 hasAuthorship W2534494590A5072856663 @default.
• W2534494590 hasAuthorship W2534494590A5082508483 @default.
• W2534494590 hasAuthorship W2534494590A5083284785 @default.
• W2534494590 hasAuthorship W2534494590A5083493986 @default.
• W2534494590 hasAuthorship W2534494590A5090755680 @default.
• W2534494590 hasBestOaLocation W25344945901 @default.
• W2534494590 hasConcept C104317684 @default.
• W2534494590 hasConcept C141231307 @default.
• W2534494590 hasConcept C197077220 @default.

• next