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- W2534572711 abstract "To maximize ventricular pumping efficiency, determinants of cardiac oxygen (or energy) consumption should be better understood. The authors have proposed a new framework to predict cardiac oxygen consumption per beat (Vo/sub 2/) from left ventricular pressure-volume (P-V) data. The essence of the method is to obtain both Emax and PVA to correlate with Vo/sub 2/, where Emax=slope of the end-systolic P-V relation or maximum elastance, as an index of contractility, PVA=systolic P-V area as a measure of total mechanical energy of contraction=external work EW+mechanical potential energy PE. The empirical equation the authors have obtained is Vo/sub 2/=aPVA+b=aPVA+cEmax+d. Pumping efficiency (EW/Vo/sub 2/) is then given by EW/(aPVA+cEmax+d). Therefore, a maximum efficiency is achieved by minimizing the denominator by decreasing a (O/sub 2/ cost of PVA) and c (O/sub 2/ cost of Emax) besides choosing an optimal combination of PVA and Emax for a required EW per min." @default.
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- W2534572711 date "2002-12-24" @default.
- W2534572711 modified "2023-09-25" @default.
- W2534572711 title "Oxygen costs of cardiac mechanical energy and contractility" @default.
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- W2534572711 doi "https://doi.org/10.1109/iembs.1996.652831" @default.
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