FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2534582743> ?p ?o ?g. }

• W2534582743 abstract "Abstract Acetylation of the lysine 40 of α-tubulin (K40) is a post-translational modification occurring in the lumen of microtubules (MTs) and is controlled by the α-tubulin acetyl-transferase αTAT1. How αTAT1 accesses the lumen and acetylates α-tubulin there has been an open question. Here, we report that acetylation starts at open ends of MTs and progressively spreads longitudinally from there. We observed acetylation marks at the open ends of in vivo MTs re-growing after a Nocodazole block, and acetylated segments growing in length with time. Bias for MTs extremities was even more pronounced when using non-dynamic MTs extracted from HeLa cells. In contrast, K40 acetylation was mostly uniform along the length of MTs reconstituted from purified tubulin in vitro. Quantitative modelling of luminal diffusion of αTAT1 suggested that the uniform acetylation pattern observed in vitro is consistent with defects in the MT lattice providing lateral access to the lumen. Indeed, we observed that in vitro MTs are permeable to macromolecules along their shaft while cellular MTs are not. Our results demonstrate αTAT1 enters the lumen from open extremities and spreads K40 acetylation marks longitudinally along cellular MTs. This mode of tip-directed microtubule acetylation may allow for selective acetylation of subsets of microtubules." @default.
• W2534582743 created "2016-10-28" @default.
• W2534582743 creator A5015019775 @default.
• W2534582743 creator A5027115618 @default.
• W2534582743 creator A5038006733 @default.
• W2534582743 creator A5038323272 @default.
• W2534582743 creator A5042496626 @default.
• W2534582743 creator A5046885691 @default.
• W2534582743 creator A5063741633 @default.
• W2534582743 creator A5066857721 @default.
• W2534582743 creator A5084331574 @default.
• W2534582743 creator A5086707944 @default.
• W2534582743 date "2016-10-18" @default.
• W2534582743 modified "2023-10-16" @default.
• W2534582743 title "αTAT1 controls longitudinal spreading of acetylation marks from open microtubules extremities" @default.
• W2534582743 cites W1481463489 @default.
• W2534582743 cites W1585324347 @default.
• W2534582743 cites W1803436399 @default.
• W2534582743 cites W1971648238 @default.
• W2534582743 cites W1977599754 @default.
• W2534582743 cites W1984167248 @default.
• W2534582743 cites W1984513782 @default.
• W2534582743 cites W2003303711 @default.
• W2534582743 cites W2008880132 @default.
• W2534582743 cites W2009590302 @default.
• W2534582743 cites W2027031016 @default.
• W2534582743 cites W2037685033 @default.
• W2534582743 cites W2084898983 @default.
• W2534582743 cites W2086962191 @default.
• W2534582743 cites W2089393338 @default.
• W2534582743 cites W2112742525 @default.
• W2534582743 cites W2117931147 @default.
• W2534582743 cites W2127684498 @default.
• W2534582743 cites W2138224881 @default.
• W2534582743 cites W2148153432 @default.
• W2534582743 cites W2155768517 @default.
• W2534582743 cites W2159335259 @default.
• W2534582743 cites W2168331596 @default.
• W2534582743 cites W2406589013 @default.
• W2534582743 cites W2431832318 @default.
• W2534582743 doi "https://doi.org/10.1038/srep35624" @default.
• W2534582743 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5067677" @default.
• W2534582743 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27752143" @default.
• W2534582743 hasPublicationYear "2016" @default.
• W2534582743 type Work @default.
• W2534582743 sameAs 2534582743 @default.
• W2534582743 citedByCount "31" @default.
• W2534582743 countsByYear W25345827432017 @default.
• W2534582743 countsByYear W25345827432018 @default.
• W2534582743 countsByYear W25345827432019 @default.
• W2534582743 countsByYear W25345827432020 @default.
• W2534582743 countsByYear W25345827432021 @default.
• W2534582743 countsByYear W25345827432022 @default.
• W2534582743 countsByYear W25345827432023 @default.
• W2534582743 crossrefType "journal-article" @default.
• W2534582743 hasAuthorship W2534582743A5015019775 @default.
• W2534582743 hasAuthorship W2534582743A5027115618 @default.
• W2534582743 hasAuthorship W2534582743A5038006733 @default.
• W2534582743 hasAuthorship W2534582743A5038323272 @default.
• W2534582743 hasAuthorship W2534582743A5042496626 @default.
• W2534582743 hasAuthorship W2534582743A5046885691 @default.
• W2534582743 hasAuthorship W2534582743A5063741633 @default.
• W2534582743 hasAuthorship W2534582743A5066857721 @default.
• W2534582743 hasAuthorship W2534582743A5084331574 @default.
• W2534582743 hasAuthorship W2534582743A5086707944 @default.
• W2534582743 hasBestOaLocation W25345827431 @default.
• W2534582743 hasConcept C104317684 @default.
• W2534582743 hasConcept C119157956 @default.
• W2534582743 hasConcept C12554922 @default.
• W2534582743 hasConcept C131631996 @default.
• W2534582743 hasConcept C142669718 @default.
• W2534582743 hasConcept C1491633281 @default.
• W2534582743 hasConcept C185592680 @default.
• W2534582743 hasConcept C202751555 @default.
• W2534582743 hasConcept C20418707 @default.
• W2534582743 hasConcept C2779363559 @default.
• W2534582743 hasConcept C55493867 @default.
• W2534582743 hasConcept C84425145 @default.
• W2534582743 hasConcept C86803240 @default.
• W2534582743 hasConcept C95444343 @default.
• W2534582743 hasConceptScore W2534582743C104317684 @default.
• W2534582743 hasConceptScore W2534582743C119157956 @default.
• W2534582743 hasConceptScore W2534582743C12554922 @default.
• W2534582743 hasConceptScore W2534582743C131631996 @default.
• W2534582743 hasConceptScore W2534582743C142669718 @default.
• W2534582743 hasConceptScore W2534582743C1491633281 @default.
• W2534582743 hasConceptScore W2534582743C185592680 @default.
• W2534582743 hasConceptScore W2534582743C202751555 @default.
• W2534582743 hasConceptScore W2534582743C20418707 @default.
• W2534582743 hasConceptScore W2534582743C2779363559 @default.
• W2534582743 hasConceptScore W2534582743C55493867 @default.
• W2534582743 hasConceptScore W2534582743C84425145 @default.
• W2534582743 hasConceptScore W2534582743C86803240 @default.
• W2534582743 hasConceptScore W2534582743C95444343 @default.
• W2534582743 hasIssue "1" @default.
• W2534582743 hasLocation W25345827431 @default.
• W2534582743 hasLocation W25345827432 @default.
• W2534582743 hasLocation W25345827433 @default.
• W2534582743 hasLocation W25345827434 @default.
• W2534582743 hasLocation W25345827435 @default.

• next