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- W2534609774 abstract "Netrins form a family of secreted and membrane-associated proteins, netrin-1 being the prototype and most investigated member of the family. The major physiological functions of netrin-1 lie in the regulation of axonal development as well as morphogenesis of different branched organs, by promoting the polarity of migratory/invasive front of the cell. On the other hand, netrin-1 acts as a factor preventing cell apoptosis. These events are mediated via a range of different receptors, including UNC5 and DCC-families. Cancer cells often employ developmental pathways to gain survival and motility advantage. Within recent years, there has been increasing number of observations of upregulation of netrin-1 expression in different forms of cancer, and the increased expression of netrin-1 has been linked to its functions as a survival and invasion promoting factor. We review here recent advances in the netrin-1 related developmental processes that may be of special interest in tumor biology, in addition to the known functions of netrin-1 in tumor biology with special focus on cancer cell migration." @default.
- W2534609774 created "2016-10-28" @default.
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- W2534609774 date "2016-11-01" @default.
- W2534609774 modified "2023-09-27" @default.
- W2534609774 title "Netrin-1: A regulator of cancer cell motility?" @default.
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- W2534609774 doi "https://doi.org/10.1016/j.ejcb.2016.10.002" @default.
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