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• W2534671661 endingPage "147" @default.
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• W2534671661 abstract "The immune-regulatory B7-H1 receptor, also known as programmed death-ligand 1 (PD-L1), plays an important role in cell-mediated immune response. It is a co-signaling molecule that mediates regulation of T cell activation and tolerance and is able to negatively regulate activated T cell functions and survival. High expression of B7-H1 in host cells may contribute to the chronicity of inflammatory disorders and represents a possible mechanism of immune evasion. Porphyromonas gingivalis is regarded as a keystone pathogen in periodontitis and is able to invade host cells and disposes a variety of virulence factors including lipopolysaccharide (LPS), fimbriae and proteases such as gingipains. Based on previous studies that demonstrated the capability of P. gingivalis to induce up-regulation of PD-L1 in malignant and non-malignant oral epithelial cells, the aim of the present work was to analyse the potential of various cellular components of P. gingivalis to induce the PD-L1 receptor. Human squamous carcinoma cells and primary gingival keratinocytes were stimulated with total, inner and outer membrane fractions, cytosolic proteins, as well as LPS and peptidoglycans. PD-L1 protein expression was investigated by Western blot analysis and RT-PCR. It was demonstrated that the total membrane fraction induced the highest up-regulation in B7-H1 expression, followed by the outer and inner membrane, whereas cytosolic proteins and LPS did not. In conclusion, we provide evidence that the membrane fraction of P. gingivalis is responsible for up-regulation of the immune-regulatory receptor PD-L1 in squamous carcinoma cells and gingival keratinocytes, and thus may support immune evasion of oral carcinomas." @default.
• W2534671661 created "2016-10-28" @default.
• W2534671661 creator A5011627495 @default.
• W2534671661 creator A5019058431 @default.
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• W2534671661 creator A5077667921 @default.
• W2534671661 date "2017-02-01" @default.
• W2534671661 modified "2023-09-24" @default.
• W2534671661 title "Induction of B7-H1 receptor by bacterial cells fractions of Porphyromonas gingivalis on human oral epithelial cells" @default.
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• W2534671661 doi "https://doi.org/10.1016/j.imbio.2016.10.011" @default.
• W2534671661 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28164807" @default.
• W2534671661 hasPublicationYear "2017" @default.
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