Matches in SemOpenAlex for { <https://semopenalex.org/work/W2534675620> ?p ?o ?g. }
- W2534675620 endingPage "712" @default.
- W2534675620 startingPage "712" @default.
- W2534675620 abstract "Background: The role of the immune system in insulin resistance associated with type 2 diabetes has been suggested.Objectives: We assessed the profile of Th1/Th2 cytokines along with the frequencies of immune cells in insulin-treated type 2 diabetic patients (T2DP).Methods: 45 T2D patients and 43 age-matched healthy subjects were selected. Serum concentrations of T-helper type 1 (Th1) and Th2 cytokines and the frequencies of innate and adaptive immunity cells were assessed.Results: T2DP were hyperglycemic and showed high level of insulin, normal levels of triglycerides and total-cholesterol and without any change in HDL-cholesterol.Compared to healthy subjects, T2DP exhibited significant decreased frequencies of neutrophils, without any change in monocytes, eosinophils and natural killer cells. The percentages of total lymphocytes (CD3+) and CD8+-T-cells decreased whereas those of regulatory T-cells increased without any change in CD4+ T-cells in T2DP. Interestingly, the frequencies of effector CD4+-T and B-cells increased in T2DP. Serum concentrations of IL-2, IFN-γ and IL-4decreased while IL-10 significantly enhanced in T2DP, suggesting a differentiation of CD4+T helper cells towards IL-10-producing- Teff-cells in these patients.Conclusion: Insulin-treated type 2 diabetes is associated with anti-inflammatory profile consistent with differentiation of CD4+-Th-cells towards IL-10-producing-Teff-cells, concomitant with increased frequencies of Treg and B-cells, and this mayprobably offer prevention against certain infections or autoimmune/inflammatory diseases.Keywords: Type 2 diabetes, Insulin, Immune cells, Th1/Th2 polarization." @default.
- W2534675620 created "2016-10-28" @default.
- W2534675620 creator A5000646046 @default.
- W2534675620 creator A5005690081 @default.
- W2534675620 creator A5011813863 @default.
- W2534675620 creator A5012059550 @default.
- W2534675620 creator A5024151428 @default.
- W2534675620 creator A5025360451 @default.
- W2534675620 creator A5027908662 @default.
- W2534675620 creator A5032374518 @default.
- W2534675620 date "2016-10-17" @default.
- W2534675620 modified "2023-10-11" @default.
- W2534675620 title "Modulation of immune cells and Th1/Th2 cytokines in insulin-treated type 2 diabetes mellitus" @default.
- W2534675620 cites W1530044612 @default.
- W2534675620 cites W1823693822 @default.
- W2534675620 cites W1920128393 @default.
- W2534675620 cites W1964967793 @default.
- W2534675620 cites W197519492 @default.
- W2534675620 cites W1980110512 @default.
- W2534675620 cites W1980199806 @default.
- W2534675620 cites W1983982530 @default.
- W2534675620 cites W1985882893 @default.
- W2534675620 cites W1989090634 @default.
- W2534675620 cites W1994188957 @default.
- W2534675620 cites W1998221258 @default.
- W2534675620 cites W2008381613 @default.
- W2534675620 cites W2010957046 @default.
- W2534675620 cites W2012628829 @default.
- W2534675620 cites W2024144587 @default.
- W2534675620 cites W2024827332 @default.
- W2534675620 cites W2025015260 @default.
- W2534675620 cites W2026703925 @default.
- W2534675620 cites W2029466715 @default.
- W2534675620 cites W2040153748 @default.
- W2534675620 cites W2046656346 @default.
- W2534675620 cites W2051767740 @default.
- W2534675620 cites W2058361348 @default.
- W2534675620 cites W2060477269 @default.
- W2534675620 cites W2067399169 @default.
- W2534675620 cites W2071073097 @default.
- W2534675620 cites W2083741582 @default.
- W2534675620 cites W2084699548 @default.
- W2534675620 cites W2097722989 @default.
- W2534675620 cites W2109723966 @default.
- W2534675620 cites W2110630581 @default.
- W2534675620 cites W2119843949 @default.
- W2534675620 cites W2127654037 @default.
- W2534675620 cites W2140907689 @default.
- W2534675620 cites W2143055774 @default.
- W2534675620 cites W2144821774 @default.
- W2534675620 cites W2145697808 @default.
- W2534675620 cites W2146957741 @default.
- W2534675620 cites W2149023198 @default.
- W2534675620 cites W2158738033 @default.
- W2534675620 cites W2163904778 @default.
- W2534675620 cites W2165334726 @default.
- W2534675620 cites W2167619945 @default.
- W2534675620 cites W2202699460 @default.
- W2534675620 cites W2564152524 @default.
- W2534675620 cites W2792745638 @default.
- W2534675620 doi "https://doi.org/10.4314/ahs.v16i3.11" @default.
- W2534675620 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5111983" @default.
- W2534675620 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27917204" @default.
- W2534675620 hasPublicationYear "2016" @default.
- W2534675620 type Work @default.
- W2534675620 sameAs 2534675620 @default.
- W2534675620 citedByCount "37" @default.
- W2534675620 countsByYear W25346756202016 @default.
- W2534675620 countsByYear W25346756202017 @default.
- W2534675620 countsByYear W25346756202018 @default.
- W2534675620 countsByYear W25346756202019 @default.
- W2534675620 countsByYear W25346756202020 @default.
- W2534675620 countsByYear W25346756202021 @default.
- W2534675620 countsByYear W25346756202022 @default.
- W2534675620 countsByYear W25346756202023 @default.
- W2534675620 crossrefType "journal-article" @default.
- W2534675620 hasAuthorship W2534675620A5000646046 @default.
- W2534675620 hasAuthorship W2534675620A5005690081 @default.
- W2534675620 hasAuthorship W2534675620A5011813863 @default.
- W2534675620 hasAuthorship W2534675620A5012059550 @default.
- W2534675620 hasAuthorship W2534675620A5024151428 @default.
- W2534675620 hasAuthorship W2534675620A5025360451 @default.
- W2534675620 hasAuthorship W2534675620A5027908662 @default.
- W2534675620 hasAuthorship W2534675620A5032374518 @default.
- W2534675620 hasBestOaLocation W25346756201 @default.
- W2534675620 hasConcept C126322002 @default.
- W2534675620 hasConcept C134018914 @default.
- W2534675620 hasConcept C149532602 @default.
- W2534675620 hasConcept C154317977 @default.
- W2534675620 hasConcept C167672396 @default.
- W2534675620 hasConcept C193419808 @default.
- W2534675620 hasConcept C202751555 @default.
- W2534675620 hasConcept C203014093 @default.
- W2534675620 hasConcept C2777180221 @default.
- W2534675620 hasConcept C2777391703 @default.
- W2534675620 hasConcept C2779306644 @default.
- W2534675620 hasConcept C55493867 @default.
- W2534675620 hasConcept C555293320 @default.