FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W253474267> ?p ?o ?g. }

• W253474267 endingPage "272" @default.
• W253474267 startingPage "261" @default.
• W253474267 abstract "Detailed characterization of the subdermal model is a significant tool for better understanding of calcification mechanisms occurring in heart valves. In previous ultrastructural investigation on six-week-implantated aortic valve leaflets, modified pre-embedding glutaraldehyde-cuprolinic-blue reactions (GA-CB) enabled sample decalcification with concurrent retention/staining of lipid-containing polyanionic material, which lined cells and cell-derived matrix-vesicle-like bodies (phthalocyanin-positive layers: PPLs) co-localizing with the earliest apatite nucleation sites. Additional post-embedding silver staining (GA-CB-S) revealed PPLs to contain calcium-binding sites. This investigation concerns valve leaflets subjected to shorter implantation times to shed light on the modifications associated with PPLs generation and calcification onset/progression. Spectrometric estimations revealed time-dependent calcium increase, for unreacted samples, and copper modifications indicating an increase in acidic, non-glycanic material, for GA-CB-reacted samples. Two-day-implant thin sections showed emission and subsequent reabsorption of lamellipodium-like protrusions by cells, originating ECM-containing vacuoles, and/or degeneration stages characterized by the appearance of GA-CB-S-reactive, organule-derived dense bodies and progressive dissolution of all cell membranes. In one-week-implants, the first PPL-lined cells were found to co-exist with cells where GA-CB-S-reactive material accumulated, or exudated towards their edges, or outcropped at the ECM milieu, so acquiring PPL features. PPL-derived material was observed increasingly to affect the ECM on thin sections of one-week- to six-week-implants. These results show an endogenous source for PPLs and reveal that a peculiar cascade of cell degenerative steps is associated with valve mineralization in the subdermal model, providing new useful parameters for more reliable comparison of this experimental calcification process versus the physiological and pathological processes." @default.
• W253474267 created "2016-06-24" @default.
• W253474267 creator A5007064235 @default.
• W253474267 creator A5021286682 @default.
• W253474267 creator A5035314222 @default.
• W253474267 creator A5040401368 @default.
• W253474267 creator A5050566184 @default.
• W253474267 creator A5059430277 @default.
• W253474267 creator A5081879832 @default.
• W253474267 creator A5083690691 @default.
• W253474267 date "2007-03-01" @default.
• W253474267 modified "2023-09-26" @default.
• W253474267 title "Ultrastructural characterization of calcification onset and progression in subdermally implanted aortic valves. Histochemical and spectrometric data." @default.
• W253474267 cites W1497627461 @default.
• W253474267 cites W1574332089 @default.
• W253474267 cites W1592012836 @default.
• W253474267 cites W175118358 @default.
• W253474267 cites W1968512601 @default.
• W253474267 cites W1979048735 @default.
• W253474267 cites W1983529229 @default.
• W253474267 cites W1996370244 @default.
• W253474267 cites W2000172237 @default.
• W253474267 cites W200319174 @default.
• W253474267 cites W2005931658 @default.
• W253474267 cites W2014586516 @default.
• W253474267 cites W2037027210 @default.
• W253474267 cites W2038430654 @default.
• W253474267 cites W2066730611 @default.
• W253474267 cites W2085202656 @default.
• W253474267 cites W2088791095 @default.
• W253474267 cites W2101385628 @default.
• W253474267 cites W2118457257 @default.
• W253474267 cites W2124591820 @default.
• W253474267 cites W2131787811 @default.
• W253474267 cites W2145660691 @default.
• W253474267 cites W2157274342 @default.
• W253474267 cites W2160907987 @default.
• W253474267 cites W2166742825 @default.
• W253474267 cites W2166835169 @default.
• W253474267 cites W2179075248 @default.
• W253474267 cites W2217005512 @default.
• W253474267 cites W2232283924 @default.
• W253474267 cites W2288695245 @default.
• W253474267 cites W2408230865 @default.
• W253474267 cites W2409407300 @default.
• W253474267 cites W2410481986 @default.
• W253474267 cites W2413272612 @default.
• W253474267 cites W2413981344 @default.
• W253474267 cites W2414217345 @default.
• W253474267 cites W59853369 @default.
• W253474267 cites W602550906 @default.
• W253474267 doi "https://doi.org/10.14670/hh-22.261" @default.
• W253474267 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17163400" @default.
• W253474267 hasPublicationYear "2007" @default.
• W253474267 type Work @default.
• W253474267 sameAs 253474267 @default.
• W253474267 citedByCount "8" @default.
• W253474267 countsByYear W2534742672015 @default.
• W253474267 countsByYear W2534742672016 @default.
• W253474267 countsByYear W2534742672017 @default.
• W253474267 countsByYear W2534742672019 @default.
• W253474267 countsByYear W2534742672022 @default.
• W253474267 countsByYear W2534742672023 @default.
• W253474267 crossrefType "journal-article" @default.
• W253474267 hasAuthorship W253474267A5007064235 @default.
• W253474267 hasAuthorship W253474267A5021286682 @default.
• W253474267 hasAuthorship W253474267A5035314222 @default.
• W253474267 hasAuthorship W253474267A5040401368 @default.
• W253474267 hasAuthorship W253474267A5050566184 @default.
• W253474267 hasAuthorship W253474267A5059430277 @default.
• W253474267 hasAuthorship W253474267A5081879832 @default.
• W253474267 hasAuthorship W253474267A5083690691 @default.
• W253474267 hasConcept C105702510 @default.
• W253474267 hasConcept C12554922 @default.
• W253474267 hasConcept C130316041 @default.
• W253474267 hasConcept C142724271 @default.
• W253474267 hasConcept C185592680 @default.
• W253474267 hasConcept C2780309369 @default.
• W253474267 hasConcept C41625074 @default.
• W253474267 hasConcept C55493867 @default.
• W253474267 hasConcept C71924100 @default.
• W253474267 hasConcept C74864618 @default.
• W253474267 hasConcept C86803240 @default.
• W253474267 hasConcept C87555872 @default.
• W253474267 hasConceptScore W253474267C105702510 @default.
• W253474267 hasConceptScore W253474267C12554922 @default.
• W253474267 hasConceptScore W253474267C130316041 @default.
• W253474267 hasConceptScore W253474267C142724271 @default.
• W253474267 hasConceptScore W253474267C185592680 @default.
• W253474267 hasConceptScore W253474267C2780309369 @default.
• W253474267 hasConceptScore W253474267C41625074 @default.
• W253474267 hasConceptScore W253474267C55493867 @default.
• W253474267 hasConceptScore W253474267C71924100 @default.
• W253474267 hasConceptScore W253474267C74864618 @default.
• W253474267 hasConceptScore W253474267C86803240 @default.
• W253474267 hasConceptScore W253474267C87555872 @default.
• W253474267 hasIssue "3" @default.
• W253474267 hasLocation W2534742671 @default.

• next