FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2534857558> ?p ?o ?g. }

• W2534857558 endingPage "3216" @default.
• W2534857558 startingPage "3202" @default.
• W2534857558 abstract "SEE SCABER AND TALBOT DOI101093/AWW264 FOR A SCIENTIFIC COMMENTARY ON THIS ARTICLE: A GGGGCC repeat expansion in C9orf72 leads to frontotemporal dementia and/or amyotrophic lateral sclerosis. Diverse pathological features have been identified, and their disease relevance remains much debated. Here, we describe two illuminating patients with frontotemporal dementia due to the C9orf72 repeat expansion. Case 1 was a 65-year-old female with behavioural variant frontotemporal dementia accompanied by focal degeneration in subgenual anterior cingulate cortex, amygdala, and medial pulvinar thalamus. At autopsy, widespread RNA foci and dipeptide repeat protein inclusions were observed, but TDP-43 pathology was nearly absent, even in degenerating brain regions. Case 2 was a 74-year-old female with atypical frontotemporal dementia-motor neuron disease who underwent temporal lobe resection for epilepsy 5 years prior to her first frontotemporal dementia symptoms. Archival surgical resection tissue contained RNA foci, dipeptide repeat protein inclusions, and loss of nuclear TDP-43 but no TDP-43 inclusions despite florid TDP-43 inclusions at autopsy 8 years after first symptoms. These findings suggest that C9orf72-specific phenomena may impact brain structure and function and emerge before first symptoms and TDP-43 aggregation." @default.
• W2534857558 created "2016-10-28" @default.
• W2534857558 creator A5009592141 @default.
• W2534857558 creator A5011528405 @default.
• W2534857558 creator A5018481303 @default.
• W2534857558 creator A5019140507 @default.
• W2534857558 creator A5019819118 @default.
• W2534857558 creator A5030961156 @default.
• W2534857558 creator A5046120768 @default.
• W2534857558 creator A5048481245 @default.
• W2534857558 creator A5052536571 @default.
• W2534857558 creator A5058278504 @default.
• W2534857558 creator A5059058313 @default.
• W2534857558 creator A5062316104 @default.
• W2534857558 creator A5073901742 @default.
• W2534857558 creator A5074694043 @default.
• W2534857558 creator A5080242363 @default.
• W2534857558 creator A5086296477 @default.
• W2534857558 creator A5086394733 @default.
• W2534857558 date "2016-10-22" @default.
• W2534857558 modified "2023-10-14" @default.
• W2534857558 title "Timing and significance of pathological features in<i>C9orf72</i>expansion-associated frontotemporal dementia" @default.
• W2534857558 cites W1137678651 @default.
• W2534857558 cites W1595453527 @default.
• W2534857558 cites W1673222863 @default.
• W2534857558 cites W1772166703 @default.
• W2534857558 cites W1796096082 @default.
• W2534857558 cites W1797572428 @default.
• W2534857558 cites W1878242548 @default.
• W2534857558 cites W1974961961 @default.
• W2534857558 cites W1980894900 @default.
• W2534857558 cites W1984538960 @default.
• W2534857558 cites W1986986092 @default.
• W2534857558 cites W1998478917 @default.
• W2534857558 cites W2013131112 @default.
• W2534857558 cites W2013488820 @default.
• W2534857558 cites W2022210358 @default.
• W2534857558 cites W2034642967 @default.
• W2534857558 cites W2036427176 @default.
• W2534857558 cites W2038735530 @default.
• W2534857558 cites W2043533588 @default.
• W2534857558 cites W2048021703 @default.
• W2534857558 cites W2054068057 @default.
• W2534857558 cites W2063996210 @default.
• W2534857558 cites W2065219073 @default.
• W2534857558 cites W2069171272 @default.
• W2534857558 cites W2073190029 @default.
• W2534857558 cites W2088483634 @default.
• W2534857558 cites W2092145129 @default.
• W2534857558 cites W2095798723 @default.
• W2534857558 cites W2100387338 @default.
• W2534857558 cites W2106786486 @default.
• W2534857558 cites W2114872355 @default.
• W2534857558 cites W2123193865 @default.
• W2534857558 cites W2137039075 @default.
• W2534857558 cites W2139264742 @default.
• W2534857558 cites W2150523249 @default.
• W2534857558 cites W2152018727 @default.
• W2534857558 cites W2154945114 @default.
• W2534857558 cites W2164611804 @default.
• W2534857558 cites W2165213609 @default.
• W2534857558 cites W222561556 @default.
• W2534857558 cites W2281389610 @default.
• W2534857558 doi "https://doi.org/10.1093/brain/aww250" @default.
• W2534857558 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5790143" @default.
• W2534857558 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27797809" @default.
• W2534857558 hasPublicationYear "2016" @default.
• W2534857558 type Work @default.
• W2534857558 sameAs 2534857558 @default.
• W2534857558 citedByCount "122" @default.
• W2534857558 countsByYear W25348575582016 @default.
• W2534857558 countsByYear W25348575582017 @default.
• W2534857558 countsByYear W25348575582018 @default.
• W2534857558 countsByYear W25348575582019 @default.
• W2534857558 countsByYear W25348575582020 @default.
• W2534857558 countsByYear W25348575582021 @default.
• W2534857558 countsByYear W25348575582022 @default.
• W2534857558 countsByYear W25348575582023 @default.
• W2534857558 crossrefType "journal-article" @default.
• W2534857558 hasAuthorship W2534857558A5009592141 @default.
• W2534857558 hasAuthorship W2534857558A5011528405 @default.
• W2534857558 hasAuthorship W2534857558A5018481303 @default.
• W2534857558 hasAuthorship W2534857558A5019140507 @default.
• W2534857558 hasAuthorship W2534857558A5019819118 @default.
• W2534857558 hasAuthorship W2534857558A5030961156 @default.
• W2534857558 hasAuthorship W2534857558A5046120768 @default.
• W2534857558 hasAuthorship W2534857558A5048481245 @default.
• W2534857558 hasAuthorship W2534857558A5052536571 @default.
• W2534857558 hasAuthorship W2534857558A5058278504 @default.
• W2534857558 hasAuthorship W2534857558A5059058313 @default.
• W2534857558 hasAuthorship W2534857558A5062316104 @default.
• W2534857558 hasAuthorship W2534857558A5073901742 @default.
• W2534857558 hasAuthorship W2534857558A5074694043 @default.
• W2534857558 hasAuthorship W2534857558A5080242363 @default.
• W2534857558 hasAuthorship W2534857558A5086296477 @default.
• W2534857558 hasAuthorship W2534857558A5086394733 @default.
• W2534857558 hasBestOaLocation W25348575581 @default.
• W2534857558 hasConcept C142724271 @default.

• next