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- W2534978026 abstract "It is essential to determine specificity of AV-1451 PET by using neuropathologic comparisons. We performed autoradiography in autopsy-confirmed Alzheimer’s disease (AD) and other neurodegenerative disorders to evaluate the specificity of AV-1451 binding for tau aggregates. Tissue samples were selected that had a variety of dementia-related neuropathologies (n=37). Brain tissue sections were stained for tau, TDP-43, and α-synuclein and compared to adjacent sections processed for AV-1451 autoradiography. In AD, AV-1451 preferentially localized to neurofibrillary tangles, with less binding to areas enriched in neuritic pathology. The strength of AV-1451 binding with respect to tau isoforms that preferentially accumulate in various neurodegenerative disorders was as follows: 3R+4R tau (e.g., AD) > 3R tau (e.g., Pick’s disease) > 4R tau. Only modest binding of AV-1451 to TDP-43 was detected. No binding of AV-1451 to α-synuclein was detected. “Off-target” binding was seen in vasculature, iron-associated regions, substantia nigra, calcifications in the choroid plexus, and leptomeningeal melanin." @default.
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- W2534978026 date "2016-07-01" @default.
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- W2534978026 title "IC-01-05: Neuropathologic Features of AV1451 TAU Pet Autoradiography in Dementia" @default.
- W2534978026 doi "https://doi.org/10.1016/j.jalz.2016.06.065" @default.
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