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• W2535084772 abstract "Cortical gray matter (GM) decline is a hallmark of neurodegenerative disease; however, its etiology and implication in dementia-free aging is unclear. The aims of this study were to: 1) investigate the impact of cortical thickness on cognition, and, 2) examine systemic inflammation and cerebrovascular disease (CVD) as potential risk factors for GM degeneration. 91 dementia-free Okinawan participants (mean age 83.6) from the Keys to Optimal Cognitive Aging (KOCOA) Project underwent MRI, cognitive, and physical evaluation. Mean cortical thickness (MCT) was derived using FreeSurfer. Serum markers of inflammation and CVD risk were obtained. CVD risk status was calculated based on >2 of the following: ever smoked, glycosylated hemoglobin >5.6, systolic blood pressure > 139, taking anti-hypertension medication, serum triglyceride >150, and high density lipoprotein < 40 in men, or < 50 in women. Inflammatory markers included: interleukin-6 (IL6) and high-sensitivity C-reactive protein (hsCRP). Subjects were surveyed regarding physical activities (PA), including walking and yoga. Multivariate analyses examined relationships between MCT and memory (mini mental word recall) and executive function (verbal fluency). Spearman’s rank order correlation or t-tests examined the relationships between MCT and: age, PA, CVD risk, and inflammatory markers. Voxel based morphometry (VBM) examined relationships between regional GM density and factors significant in the previous univariate analysis. Exploratory analyses examined systemic inflammation in relation to PA. After adjusting for age, gender, and %hippo volume, decreased MCT was associated with worse memory, but not executive function. In univariate analyses, decreased MCT was associated with increased IL6 (0.04), but not with age, PA, hsCRP or CVD risk. VBM analysis demonstrated greater IL6 to be associated with decreased cortical density in the inferior and middle temporal cortex, bilaterally. After adjusting for age and gender, greater yoga participation (p = 0.02), but not walking, was associated with lower IL6 levels. Decreased MCT is associated with worse memory performance in dementia free-Okinawans. Greater IL6 was related to decreased temporal lobe cortical thickness, and decreased PA. Low-impact stretch activities, such as yoga, should be further explored as potential ways to decrease systemic inflammation and prevent cortical thinning and memory loss in older individuals. VBM analysis with threshold-free cluster enhancement and permutation testing to correct for multiple comparisons. Colored voxels indicate regions of decreased GM density significantly associated with higher IL6, age and gender adjusted. Serum IL6 in relation to yoga frequency (p = 0.02 in final model adjusted for age and gender)." @default.
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• W2535084772 date "2016-07-01" @default.
• W2535084772 modified "2023-09-26" @default.
• W2535084772 title "IC-P-112: Risk Factors Associated With Decreased Cortical Thickness in Dementia Free Okinawan Elderly" @default.
• W2535084772 doi "https://doi.org/10.1016/j.jalz.2016.06.142" @default.
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