Matches in SemOpenAlex for { <https://semopenalex.org/work/W2535145947> ?p ?o ?g. }
- W2535145947 endingPage "66" @default.
- W2535145947 startingPage "52" @default.
- W2535145947 abstract "Tissue engineering strategies have shown promise in promoting healing and regeneration after spinal cord injury (SCI); however, these strategies are limited by inflammation and the immune response. Infiltration of cells of the innate and adaptive immune responses and the inflammation that follows cause secondary damage adjacent to the injury, increased scarring, and a potently inhibitory environment for the regeneration of damaged neurons. While the inflammation that ensues is typically associated with limited regeneration, the immune response is a crucial element in the closing of the blood-brain barrier, minimizing the spread of injury, and initiating healing. This review summarizes the strategies that have been developed to modulate the immune response towards an anti-inflammatory environment that is permissive to the regeneration of neurons, glia, and parenchyma. We focus on the use of biomaterials, biologically active molecules, gene therapy, nanoparticles, and stem cells to modulate the immune response, and illustrate concepts for future therapies. Current clinical treatments for SCI are limited to systemic hypothermia or methylprednisolone, which both act by systemically mitigating the effects of immune response but have marginal efficacy. Herein, we discuss emerging research strategies to further enhance these clinical treatments by directly targeting specific aspects of the immune response." @default.
- W2535145947 created "2016-10-28" @default.
- W2535145947 creator A5006241989 @default.
- W2535145947 creator A5008236359 @default.
- W2535145947 creator A5083516725 @default.
- W2535145947 date "2016-01-01" @default.
- W2535145947 modified "2023-10-16" @default.
- W2535145947 title "Tissue Engineering Approaches to Modulate the Inflammatory Milieu following Spinal Cord Injury" @default.
- W2535145947 cites W1489759013 @default.
- W2535145947 cites W1514448870 @default.
- W2535145947 cites W1548202935 @default.
- W2535145947 cites W1556182045 @default.
- W2535145947 cites W1559912603 @default.
- W2535145947 cites W1570742130 @default.
- W2535145947 cites W1595606162 @default.
- W2535145947 cites W1602964111 @default.
- W2535145947 cites W1603796090 @default.
- W2535145947 cites W1648125567 @default.
- W2535145947 cites W1806924313 @default.
- W2535145947 cites W1820447334 @default.
- W2535145947 cites W1874586944 @default.
- W2535145947 cites W1895934305 @default.
- W2535145947 cites W1908112684 @default.
- W2535145947 cites W1944874974 @default.
- W2535145947 cites W1966343604 @default.
- W2535145947 cites W1967109943 @default.
- W2535145947 cites W1967850823 @default.
- W2535145947 cites W1969609722 @default.
- W2535145947 cites W1970476447 @default.
- W2535145947 cites W1970901436 @default.
- W2535145947 cites W1971165182 @default.
- W2535145947 cites W1971865391 @default.
- W2535145947 cites W1974556119 @default.
- W2535145947 cites W1974747930 @default.
- W2535145947 cites W1977735016 @default.
- W2535145947 cites W1978684572 @default.
- W2535145947 cites W1981505729 @default.
- W2535145947 cites W1982284164 @default.
- W2535145947 cites W1982490601 @default.
- W2535145947 cites W1983237008 @default.
- W2535145947 cites W1985040895 @default.
- W2535145947 cites W1985859986 @default.
- W2535145947 cites W1986628684 @default.
- W2535145947 cites W1987448478 @default.
- W2535145947 cites W1989059501 @default.
- W2535145947 cites W1990228542 @default.
- W2535145947 cites W1990616239 @default.
- W2535145947 cites W1991164200 @default.
- W2535145947 cites W1991707014 @default.
- W2535145947 cites W1993895495 @default.
- W2535145947 cites W1996386974 @default.
- W2535145947 cites W2000430876 @default.
- W2535145947 cites W2001295401 @default.
- W2535145947 cites W2002824497 @default.
- W2535145947 cites W2010882645 @default.
- W2535145947 cites W2011361505 @default.
- W2535145947 cites W2011943543 @default.
- W2535145947 cites W2012468912 @default.
- W2535145947 cites W2013152171 @default.
- W2535145947 cites W2013952964 @default.
- W2535145947 cites W2014179704 @default.
- W2535145947 cites W2015952490 @default.
- W2535145947 cites W2016293419 @default.
- W2535145947 cites W2016744980 @default.
- W2535145947 cites W2019541848 @default.
- W2535145947 cites W2019583561 @default.
- W2535145947 cites W2019736713 @default.
- W2535145947 cites W2019811317 @default.
- W2535145947 cites W2020744745 @default.
- W2535145947 cites W2022286567 @default.
- W2535145947 cites W2022467177 @default.
- W2535145947 cites W2023053568 @default.
- W2535145947 cites W2024894253 @default.
- W2535145947 cites W2029768920 @default.
- W2535145947 cites W2031268185 @default.
- W2535145947 cites W2032869696 @default.
- W2535145947 cites W2033282031 @default.
- W2535145947 cites W2034093757 @default.
- W2535145947 cites W2035551042 @default.
- W2535145947 cites W2037033434 @default.
- W2535145947 cites W2039420382 @default.
- W2535145947 cites W2044376274 @default.
- W2535145947 cites W2049625461 @default.
- W2535145947 cites W2050014457 @default.
- W2535145947 cites W2053103428 @default.
- W2535145947 cites W2054198357 @default.
- W2535145947 cites W2056336363 @default.
- W2535145947 cites W2056448943 @default.
- W2535145947 cites W2058859963 @default.
- W2535145947 cites W2059028717 @default.
- W2535145947 cites W2061653501 @default.
- W2535145947 cites W2063079110 @default.
- W2535145947 cites W2063869333 @default.
- W2535145947 cites W2064253792 @default.
- W2535145947 cites W2065700461 @default.
- W2535145947 cites W2068572014 @default.
- W2535145947 cites W2068906840 @default.
- W2535145947 cites W2073631169 @default.