FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2535163905> ?p ?o ?g. }

• W2535163905 endingPage "946" @default.
• W2535163905 startingPage "940" @default.
• W2535163905 abstract "The primary physiological function of Krüppel-like zinc-finger transcription factor (KLF5) is the regulation of cardiovascular remodeling. Vascular remodeling is closely related to the amelioration of various ischemic diseases. However, the underlying correlation of KLF5 and ischemia is not clear. In this study, we aim to investigate the role of KLF5 in myocardial ischemia reperfusion (IR) injury and the potential mechanisms involved. Cultured H9C2 cells were subjected to oxygen-glucose deprivation/reperfusion (OGD/Rep) to mimic myocardial IR injury in vivo. Expressions of KLF5 and PPARγ were distinctly inhibited, and PGC-1α expression was activated at 24 h after myocardial OGD/Rep injury. After myocardial OGD/Rep injury, we found that KLF5 overexpression down-regulated levels of TNF-α, IL-1β, IL-6 and IL-8. Through the analysis of lactate dehydrogenase (LDH) release, we demonstrate that KLF5 overexpression reduced the release of OGD/Rep-induced LDH. KLF5 overexpression significantly enhanced cell activity and decreased cell apoptosis during OGD/Rep injury. Compared with the OGD/Rep group, cells overexpressing KLF5 showed anti-apoptotic effects, such as decreased expression of Bax and cleaved caspase-3 as well as increased Bcl-2 expression. KLF5 overexpression activated PPARγ, a protein involved in OGD/Rep injury, and increased levels of PGC-1α, while TNF-α expression was remarkably inhibited. In addition, GW9662, a PPARγ receptor antagonist, reversed the expression of PPARγ/PGC-1α/TNF-α and cell activity induced by KLF5 overexpression. The effects of KLF5 overexpression on PPARγ/PGC-1α/TNF-α and cell activity were abolished by co-treatment with GW9662. Taken together, these results suggest that KLF5 can efficiently alleviate OGD/Rep-induced myocardial injury, perhaps through regulation of the PPARγ/PGC-1α/TNF-α pathway." @default.
• W2535163905 created "2016-10-28" @default.
• W2535163905 creator A5019838573 @default.
• W2535163905 creator A5028855927 @default.
• W2535163905 creator A5050839748 @default.
• W2535163905 creator A5067137302 @default.
• W2535163905 creator A5083163675 @default.
• W2535163905 date "2016-12-01" @default.
• W2535163905 modified "2023-10-18" @default.
• W2535163905 title "KLF5 overexpression attenuates cardiomyocyte inflammation induced by oxygen-glucose deprivation/reperfusion through the PPARγ/PGC-1α/TNF-α signaling pathway" @default.
• W2535163905 cites W1981520304 @default.
• W2535163905 cites W1987538872 @default.
• W2535163905 cites W2000157221 @default.
• W2535163905 cites W2013668219 @default.
• W2535163905 cites W2016986936 @default.
• W2535163905 cites W2032869210 @default.
• W2535163905 cites W2048506983 @default.
• W2535163905 cites W2052806765 @default.
• W2535163905 cites W2058165240 @default.
• W2535163905 cites W2058656796 @default.
• W2535163905 cites W2063229731 @default.
• W2535163905 cites W2066426973 @default.
• W2535163905 cites W2081077857 @default.
• W2535163905 cites W2084628164 @default.
• W2535163905 cites W2084758891 @default.
• W2535163905 cites W2087354111 @default.
• W2535163905 cites W2087393295 @default.
• W2535163905 cites W2091910407 @default.
• W2535163905 cites W2095214727 @default.
• W2535163905 cites W2113253499 @default.
• W2535163905 cites W2117031630 @default.
• W2535163905 cites W2117571600 @default.
• W2535163905 cites W2129103503 @default.
• W2535163905 cites W2150781317 @default.
• W2535163905 cites W2151911209 @default.
• W2535163905 cites W2178821248 @default.
• W2535163905 cites W2180275070 @default.
• W2535163905 cites W2410802181 @default.
• W2535163905 cites W4253422011 @default.
• W2535163905 cites W629371316 @default.
• W2535163905 doi "https://doi.org/10.1016/j.biopha.2016.09.100" @default.
• W2535163905 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27764756" @default.
• W2535163905 hasPublicationYear "2016" @default.
• W2535163905 type Work @default.
• W2535163905 sameAs 2535163905 @default.
• W2535163905 citedByCount "23" @default.
• W2535163905 countsByYear W25351639052017 @default.
• W2535163905 countsByYear W25351639052018 @default.
• W2535163905 countsByYear W25351639052019 @default.
• W2535163905 countsByYear W25351639052020 @default.
• W2535163905 countsByYear W25351639052021 @default.
• W2535163905 countsByYear W25351639052022 @default.
• W2535163905 countsByYear W25351639052023 @default.
• W2535163905 crossrefType "journal-article" @default.
• W2535163905 hasAuthorship W2535163905A5019838573 @default.
• W2535163905 hasAuthorship W2535163905A5028855927 @default.
• W2535163905 hasAuthorship W2535163905A5050839748 @default.
• W2535163905 hasAuthorship W2535163905A5067137302 @default.
• W2535163905 hasAuthorship W2535163905A5083163675 @default.
• W2535163905 hasConcept C104317684 @default.
• W2535163905 hasConcept C126322002 @default.
• W2535163905 hasConcept C127561419 @default.
• W2535163905 hasConcept C134018914 @default.
• W2535163905 hasConcept C1491633281 @default.
• W2535163905 hasConcept C170493617 @default.
• W2535163905 hasConcept C173396325 @default.
• W2535163905 hasConcept C17991360 @default.
• W2535163905 hasConcept C181199279 @default.
• W2535163905 hasConcept C185592680 @default.
• W2535163905 hasConcept C187345961 @default.
• W2535163905 hasConcept C190283241 @default.
• W2535163905 hasConcept C2776914184 @default.
• W2535163905 hasConcept C2777318727 @default.
• W2535163905 hasConcept C2780114680 @default.
• W2535163905 hasConcept C541997718 @default.
• W2535163905 hasConcept C55493867 @default.
• W2535163905 hasConcept C71924100 @default.
• W2535163905 hasConcept C86339819 @default.
• W2535163905 hasConcept C86803240 @default.
• W2535163905 hasConcept C98274493 @default.
• W2535163905 hasConceptScore W2535163905C104317684 @default.
• W2535163905 hasConceptScore W2535163905C126322002 @default.
• W2535163905 hasConceptScore W2535163905C127561419 @default.
• W2535163905 hasConceptScore W2535163905C134018914 @default.
• W2535163905 hasConceptScore W2535163905C1491633281 @default.
• W2535163905 hasConceptScore W2535163905C170493617 @default.
• W2535163905 hasConceptScore W2535163905C173396325 @default.
• W2535163905 hasConceptScore W2535163905C17991360 @default.
• W2535163905 hasConceptScore W2535163905C181199279 @default.
• W2535163905 hasConceptScore W2535163905C185592680 @default.
• W2535163905 hasConceptScore W2535163905C187345961 @default.
• W2535163905 hasConceptScore W2535163905C190283241 @default.
• W2535163905 hasConceptScore W2535163905C2776914184 @default.
• W2535163905 hasConceptScore W2535163905C2777318727 @default.
• W2535163905 hasConceptScore W2535163905C2780114680 @default.
• W2535163905 hasConceptScore W2535163905C541997718 @default.
• W2535163905 hasConceptScore W2535163905C55493867 @default.
• W2535163905 hasConceptScore W2535163905C71924100 @default.

• next