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- W2535351984 abstract "Alzheimer's disease (AD) is a neurodegenerative disease with high prevalence and morbidity, for which there are no effective therapies. Soluble oligomers of the amyloid-β peptide (AβOs) are the main neurotoxins involved in the early synaptic dysfunction and oxidative stress associated with the disease. The therapeutic potential of bone marrow mesenchymal stem cells (MSCs) has been investigated in several models of neurological diseases and the main mechanism of action of these cells is based on paracrine signaling, through the release of trophic or neuroprotective factors.The aim of the current study was to evaluate the neuroprotective actions of MSCs against the deleterious effects caused by exposure of hippocampal neurons to AβOs. For this, we established a model of indirect coculture of neurons and MSCs. Here, we report for the first time that MSCs protect neurons against oxidative stress and synaptic failure through internalization and degradation of the extracellular AβOs, as well as by the release of extracellular vesicles containing the antioxidant enzyme catalase. Taken together, our data suggest that mesenchymal stem cells may represent a promising therapeutic alternative for the treatment of Alzheimer’s disease." @default.
- W2535351984 created "2016-10-28" @default.
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- W2535351984 date "2016-07-01" @default.
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- W2535351984 title "O2-02-06: Mesenchymal Stem Cells Protect Neurons Against Oxidative Stress and Synaptic Failure Induced by Oligomers of the Amyloid-B PEPTIDE (AB OS) Through Catalase Release and AB OS Clearance" @default.
- W2535351984 doi "https://doi.org/10.1016/j.jalz.2016.06.404" @default.
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