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- W2535535428 abstract "T aim of the present work was to obtain and characterize new compounds which exhibit antimicrobial properties and are efficient in treatment of multidrug resistant infections. The first stage of the synthesis of the compounds N-(p-clorofenil)-N’(2-tenoil)-tiourea (1), N-(p-iodofenil)-N’-(2-tenoil)-tiourea (2), N-(p-bromofenil)-N’-(2-tenoil)-tiourea (3), N-(p-metoxifenil)-N’(2-tenoil)-tiourea (4), N-(p-metilfenil)-N’-(2-tienil)-tiourea (5), N-(p-metilfenil)-N’-(2-tenoil)-tiourea (6), N-(p-metilfenil)-N’-(3tenoil)-tiourea (7) takes place in anhydrous medium for the prevention of acids chloride decomposition in the presence of water trace. In the second stage, the samples were treated with ammonium thiocyanate which was priory dried at 100oC. The inclusion compounds between 2-hydroxypropyl-β-cyclodextrin (HP-β-CD) and some new 2-thiophene carboxylic acid thioureides were also obtained. HP-β-CD is designed to have a high solubility and ability to complex a wide range of molecules with different degree of hydrophobicity. Complexation in organic solvent method was used to obtain the solid complexes with 1:1 stoichiometry. The solid powders of pure thioureides, HP-β-CD and complexes HP-β-CD/thioureide were analyzed by thermal methods (TG/DSC), UV-Vis spectrophotometry and Fourier transform-infrared spectroscopy (FT-IR). The fusion enthalpies of the all pure compounds are: 26.0 kJ/mol (1), 27.6 kJ/mol (2), 22.6 kJ/mol (3), 29.5 kJ/mol (4), 27.3 kJ/mol (5), 22.1 kJ/mol (6), 27.4 kJ/mol (7). Pharmacologically, the analgesic effect by chemical stimulus test and the anti inflammatory effect after intra-plantar administration of dextran and caolin have been performed. Sample (3) has a slightly less analgesic effect compared to acetylsalicylic acid and the sample (4) shows the most intense anti inflammatory action, probably through a cyclooxygenase inhibition mechanism." @default.
- W2535535428 created "2016-10-28" @default.
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- W2535535428 date "2015-10-01" @default.
- W2535535428 modified "2023-09-24" @default.
- W2535535428 title "Synthesis and characterization of pure thioureides and its inclusion complexes with 2-hydroxypropyl- β-cyclodextrin (HP-β-CD)" @default.
- W2535535428 hasPublicationYear "2015" @default.
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