Matches in SemOpenAlex for { <https://semopenalex.org/work/W2535558810> ?p ?o ?g. }
- W2535558810 endingPage "1411" @default.
- W2535558810 startingPage "1411" @default.
- W2535558810 abstract "In this study, a hydroalcoholic chestnut shell extract was characterized and tested on six different human cell lines. Gallic, ellagic, and syringic acids were the most abundant non-condensed compounds in the chestnut extract, as determined by high performance liquid chromatography (HPLC). Tannins were mainly represented by condensed monomeric units of epigallocatechin and catechin/epicatechin. After 48 h of treatment, only the human hepatoblastoma HepG2 cells reached an inhibition corresponding to IC50 with an increase of apoptosis and mitochondrial depolarization. The cytokinome evaluation before and after treatment revealed that the vascular endothelial growth factor (VEGF) and the tumor necrosis factor (TNF)-α decreased after the treatment, suggesting a potential anti-angiogenic and anti-inflammatory effect of this extract. Moreover, the metabolome evaluation by ¹H-NMR evidenced that the polyphenols extracted from chestnut shell (PECS) treatment affected the levels of some amino acids and other metabolites. Overall, these data highlight the effects of biomolecules on cell proliferation, apoptosis, cell cycle and mitochondrial depolarization, and on cytokinomics and metabolomics profiles." @default.
- W2535558810 created "2016-10-28" @default.
- W2535558810 creator A5007711668 @default.
- W2535558810 creator A5012721453 @default.
- W2535558810 creator A5035309184 @default.
- W2535558810 creator A5035710316 @default.
- W2535558810 creator A5037722229 @default.
- W2535558810 creator A5050398954 @default.
- W2535558810 creator A5052593572 @default.
- W2535558810 creator A5055281776 @default.
- W2535558810 creator A5056256348 @default.
- W2535558810 creator A5059201806 @default.
- W2535558810 date "2016-10-21" @default.
- W2535558810 modified "2023-10-16" @default.
- W2535558810 title "Potential Anticancer Effects of Polyphenols from Chestnut Shell Extracts: Modulation of Cell Growth, and Cytokinomic and Metabolomic Profiles" @default.
- W2535558810 cites W1240291967 @default.
- W2535558810 cites W131351356 @default.
- W2535558810 cites W1816860758 @default.
- W2535558810 cites W1871181821 @default.
- W2535558810 cites W1914622032 @default.
- W2535558810 cites W1970335548 @default.
- W2535558810 cites W1976327004 @default.
- W2535558810 cites W1979189704 @default.
- W2535558810 cites W1980600429 @default.
- W2535558810 cites W1984011616 @default.
- W2535558810 cites W1984034918 @default.
- W2535558810 cites W1984358846 @default.
- W2535558810 cites W1986072191 @default.
- W2535558810 cites W1988284899 @default.
- W2535558810 cites W1995466995 @default.
- W2535558810 cites W1996118754 @default.
- W2535558810 cites W1996976575 @default.
- W2535558810 cites W1998432440 @default.
- W2535558810 cites W2006522226 @default.
- W2535558810 cites W2007005024 @default.
- W2535558810 cites W2008757142 @default.
- W2535558810 cites W2010668253 @default.
- W2535558810 cites W2020243521 @default.
- W2535558810 cites W2023536393 @default.
- W2535558810 cites W2024960038 @default.
- W2535558810 cites W2032717943 @default.
- W2535558810 cites W2037818329 @default.
- W2535558810 cites W2038544675 @default.
- W2535558810 cites W2046259390 @default.
- W2535558810 cites W2046334928 @default.
- W2535558810 cites W2046737475 @default.
- W2535558810 cites W2046919127 @default.
- W2535558810 cites W2050457518 @default.
- W2535558810 cites W2057781944 @default.
- W2535558810 cites W2060162714 @default.
- W2535558810 cites W2060991208 @default.
- W2535558810 cites W2065585220 @default.
- W2535558810 cites W2069882938 @default.
- W2535558810 cites W2072552773 @default.
- W2535558810 cites W2078693224 @default.
- W2535558810 cites W2081396857 @default.
- W2535558810 cites W2089363473 @default.
- W2535558810 cites W2090569886 @default.
- W2535558810 cites W2093869461 @default.
- W2535558810 cites W2102322990 @default.
- W2535558810 cites W2112585745 @default.
- W2535558810 cites W2114004260 @default.
- W2535558810 cites W2121167179 @default.
- W2535558810 cites W2135607659 @default.
- W2535558810 cites W2150151533 @default.
- W2535558810 cites W2157195247 @default.
- W2535558810 cites W2184141705 @default.
- W2535558810 cites W73973278 @default.
- W2535558810 cites W787469672 @default.
- W2535558810 doi "https://doi.org/10.3390/molecules21101411" @default.
- W2535558810 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6273950" @default.
- W2535558810 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27775667" @default.
- W2535558810 hasPublicationYear "2016" @default.
- W2535558810 type Work @default.
- W2535558810 sameAs 2535558810 @default.
- W2535558810 citedByCount "50" @default.
- W2535558810 countsByYear W25355588102018 @default.
- W2535558810 countsByYear W25355588102019 @default.
- W2535558810 countsByYear W25355588102020 @default.
- W2535558810 countsByYear W25355588102021 @default.
- W2535558810 countsByYear W25355588102022 @default.
- W2535558810 countsByYear W25355588102023 @default.
- W2535558810 crossrefType "journal-article" @default.
- W2535558810 hasAuthorship W2535558810A5007711668 @default.
- W2535558810 hasAuthorship W2535558810A5012721453 @default.
- W2535558810 hasAuthorship W2535558810A5035309184 @default.
- W2535558810 hasAuthorship W2535558810A5035710316 @default.
- W2535558810 hasAuthorship W2535558810A5037722229 @default.
- W2535558810 hasAuthorship W2535558810A5050398954 @default.
- W2535558810 hasAuthorship W2535558810A5052593572 @default.
- W2535558810 hasAuthorship W2535558810A5055281776 @default.
- W2535558810 hasAuthorship W2535558810A5056256348 @default.
- W2535558810 hasAuthorship W2535558810A5059201806 @default.
- W2535558810 hasBestOaLocation W25355588101 @default.
- W2535558810 hasConcept C135870905 @default.
- W2535558810 hasConcept C185592680 @default.
- W2535558810 hasConcept C190283241 @default.
- W2535558810 hasConcept C21565614 @default.