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- W2535929523 abstract "Lithium has been a gold standard in the treatment of bipolar disorder (BD) for several decades. Despite a general reduction in the use of lithium over the past several years, it is effective in the management of both manic and depressive episodes in BD and continues to be recommended as a first-line mood stabilizer. This review provides an overview of the pharmacology of lithium and highlights its clinical profile in the management of BD, focusing on the potential advantages of prolonged-release (PR) versus immediate-release (IR) formulations of lithium. A literature search using PubMed was performed to identify articles describing IR and PR lithium in BD using specific search terms like 'lithium', 'prolonged-release', 'sustained-release', 'extended-release', 'bipolar disorder', 'adherence' and 'compliance'. Relevant pharmacodynamic and pharmacokinetic data were also included. Several clinical trials suggested that lithium is effective in the treatment of acute mania and prophylaxis of BD and reduces the risk of suicide in patients with BD; it may also be used in combination with other drugs in the treatment of bipolar depression. Treatment with lithium must be monitored to avoid lithium-associated toxicity. The prolonged PR formulation of lithium has several advantages including consistent serum lithium concentrations, fewer adverse events and improved adherence to therapy. Although direct comparative studies between PR and IR formulations of lithium are primarily limited to pharmacokinetic studies, PR formulation of lithium provides potential advantages over IR formulation and can be effectively used in the management of BD with lesser adverse events." @default.
- W2535929523 created "2016-10-28" @default.
- W2535929523 creator A5004915779 @default.
- W2535929523 creator A5054982285 @default.
- W2535929523 creator A5056789152 @default.
- W2535929523 creator A5068204379 @default.
- W2535929523 date "2016-10-21" @default.
- W2535929523 modified "2023-10-16" @default.
- W2535929523 title "Lithium in Bipolar Disorder: Optimizing Therapy Using Prolonged-Release Formulations" @default.
- W2535929523 cites W1214861912 @default.
- W2535929523 cites W127075272 @default.
- W2535929523 cites W144595099 @default.
- W2535929523 cites W1481112428 @default.
- W2535929523 cites W1537538750 @default.
- W2535929523 cites W1560970226 @default.
- W2535929523 cites W170453689 @default.
- W2535929523 cites W1806022048 @default.
- W2535929523 cites W1897293406 @default.
- W2535929523 cites W1931062584 @default.
- W2535929523 cites W1938837379 @default.
- W2535929523 cites W1966127736 @default.
- W2535929523 cites W1969114959 @default.
- W2535929523 cites W1974004995 @default.
- W2535929523 cites W1974639348 @default.
- W2535929523 cites W1974708550 @default.
- W2535929523 cites W1976275114 @default.
- W2535929523 cites W1981207331 @default.
- W2535929523 cites W1984001932 @default.
- W2535929523 cites W1984344128 @default.
- W2535929523 cites W1987450550 @default.
- W2535929523 cites W1989190407 @default.
- W2535929523 cites W1991321137 @default.
- W2535929523 cites W1991545546 @default.
- W2535929523 cites W1996939772 @default.
- W2535929523 cites W1998678846 @default.
- W2535929523 cites W2001225160 @default.
- W2535929523 cites W2008814488 @default.
- W2535929523 cites W2013338416 @default.
- W2535929523 cites W2014754654 @default.
- W2535929523 cites W2017285479 @default.
- W2535929523 cites W2019712800 @default.
- W2535929523 cites W2020888164 @default.
- W2535929523 cites W2021436354 @default.
- W2535929523 cites W2028449820 @default.
- W2535929523 cites W2029657904 @default.
- W2535929523 cites W2034480582 @default.
- W2535929523 cites W2036118714 @default.
- W2535929523 cites W2041034708 @default.
- W2535929523 cites W2047688441 @default.
- W2535929523 cites W2048973231 @default.
- W2535929523 cites W2049031623 @default.
- W2535929523 cites W2049597587 @default.
- W2535929523 cites W2061070907 @default.
- W2535929523 cites W2064119051 @default.
- W2535929523 cites W2066578649 @default.
- W2535929523 cites W2070306252 @default.
- W2535929523 cites W2072354061 @default.
- W2535929523 cites W2072722131 @default.
- W2535929523 cites W2074535951 @default.
- W2535929523 cites W2078925876 @default.
- W2535929523 cites W2082072402 @default.
- W2535929523 cites W2084399232 @default.
- W2535929523 cites W2085206080 @default.
- W2535929523 cites W2090784587 @default.
- W2535929523 cites W2091962144 @default.
- W2535929523 cites W2093501279 @default.
- W2535929523 cites W2094486669 @default.
- W2535929523 cites W2098161537 @default.
- W2535929523 cites W2099017168 @default.
- W2535929523 cites W2099302241 @default.
- W2535929523 cites W2110363999 @default.
- W2535929523 cites W2110599035 @default.
- W2535929523 cites W2113823824 @default.
- W2535929523 cites W2117178110 @default.
- W2535929523 cites W2118826874 @default.
- W2535929523 cites W2121715917 @default.
- W2535929523 cites W2123194715 @default.
- W2535929523 cites W2124044664 @default.
- W2535929523 cites W2124464240 @default.
- W2535929523 cites W2126782872 @default.
- W2535929523 cites W2130040176 @default.
- W2535929523 cites W2132972638 @default.
- W2535929523 cites W2143438415 @default.
- W2535929523 cites W2160231464 @default.
- W2535929523 cites W2170319894 @default.
- W2535929523 cites W2179185741 @default.
- W2535929523 cites W2185709237 @default.
- W2535929523 cites W2246538314 @default.
- W2535929523 cites W2345733617 @default.
- W2535929523 cites W2754834049 @default.
- W2535929523 cites W4247665917 @default.
- W2535929523 cites W4250720969 @default.
- W2535929523 cites W4376453279 @default.
- W2535929523 cites W58289626 @default.
- W2535929523 cites W67314136 @default.
- W2535929523 cites W871677187 @default.
- W2535929523 doi "https://doi.org/10.1007/s40268-016-0139-7" @default.
- W2535929523 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5114200" @default.