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• W2535999000 abstract "Purpose . To evaluate ileorectal anastomosis (IRA) in selected ulcerative colitis patients. Methods . Early and late complications after IRA and IPAA were investigated. Bowel function and quality of life were assessed. Functional and QoL studies were performed as a matched pair analysis, comparing 98 patients who underwent IRA versus 98 patients who underwent IPAA. Results . In IRA group, 2 patients (1.6%) developed anastomotic l dysplasia (HGD) developed in 3 patients dysplasia (HGD) developed in 3 patients eakage, 1 patient (0.8%) had intestinal obstruction, and 2 patients (1.6%) had abdominal hematoma. Mean follow-up was 11.5 (range: 2–24.3) years. Failure of IRA occurred in 19 patients (15.1%); in 12 patients (9.5%), failure was related to severe proctitis, in 3 patients (2.4%), it was related to the development of high-grade dysplasia, and in 4 patients (3.2%), it was related to the development of rectal cancer. About functional results, stool consistency [liquid (6.7% of IRA patients versus 29% of IPAA patients;<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M1><mml:mi>p</mml:mi><mml:mo>=</mml:mo><mml:mn fontstyle=italic>0.003</mml:mn></mml:math>)], daily soiling (0% versus 6%;<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M2><mml:mi>p</mml:mi><mml:mo>=</mml:mo><mml:mn fontstyle=italic>0.01</mml:mn></mml:math>), and nocturnal soiling (6% versus 25.5%;<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M3><mml:mi>p</mml:mi><mml:mo>=</mml:mo><mml:mn fontstyle=italic>0.03</mml:mn></mml:math>) were statistically different. Only 1% of IRA patients versus 11% of IPAA patients had episodes of perianal inflammation (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M4><mml:mi>p</mml:mi><mml:mo>=</mml:mo><mml:mn fontstyle=italic>0.007</mml:mn></mml:math>). CGQoL was 0.72 (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M5><mml:mo>±</mml:mo><mml:mn fontstyle=italic>0.14</mml:mn></mml:math>, SD) in IRA patients and 0.75 (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M6><mml:mo>±</mml:mo><mml:mn fontstyle=italic>0.11</mml:mn></mml:math>, SD) in IPAA patients (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M7><mml:mi>p</mml:mi><mml:mo>=</mml:mo><mml:mi mathvariant=normal>n</mml:mi><mml:mi mathvariant=normal>s</mml:mi></mml:math>). Conclusion . In selected patients, IRA is an appropriate surgical option, with low morbidity, comparable quality of life, and better functional results than IPAA." @default.
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• W2535999000 date "2016-01-01" @default.
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• W2535999000 title "Could Total Colectomy with Ileorectal Anastomosis Be an Alternative to Total Proctocolectomy with Ileal Pouch-Anal Anastomosis in Selected Ulcerative Colitis Patients?" @default.
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• W2535999000 doi "https://doi.org/10.1155/2016/5832743" @default.
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