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- W2536002337 abstract "Summary. After the electron microscopic examination of tissue samples of juvenile nasopharyngeal angiofibromas obtained from 9 male patients ranging in their age from 7-24 years the problems of cytogenesis and classifcation are discussed. Besides it is tried to correlate particular morphological findings to certain clinical phenomenons. The vascular component of juvenile nasopharyngeal angiofibromas shows a clear proliferation of the vascular wall cells. Particularly, proliferating pericytes, cells withous peculiar characteristics (undifferentiated cells) and cells in various stages of differentiation are to be emphasized. Obviously, vascular wall cells emigrate into the surrounding tissue and transform themselves into small fibroblasts. The second component of juvenile nasopharyngeal angiofibromas is represented by stromal fibroblasts with several cytological variations. Only activated classical fibroblasts and fibroblasts with histiocyte-like features reveal the nuclear pattern unique for these growths which is characterized by the combination of protrusions of nuclear membrane with formation of nuclear blebs and of dense intranuclear granules. Cells with these nuclear characteristics were considered as preexisting fibroblasts. Thus juvenile nasopharyngeal angiofibromas are formed by the proliferation of two tissue components, namely by the proliferation of vascular wall cells and stromal fibroblasts, and can be conceived as reactive hyperplasias. The swelling body-like and organoid appearance, cytological pecularities, characteristic topographic relations (localization and supplying vessels) and the sex-dependent occurrence speak for a tumor-like hyperplasia of a rudimentary organ unknown till now." @default.
- W2536002337 created "2016-10-28" @default.
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- W2536002337 date "1977-01-01" @default.
- W2536002337 modified "2023-09-24" @default.
- W2536002337 title "Elektronenmikros kopisehe Untersuehungen zur Zytogenese des juvenilen Nasenraehenfibro ms" @default.
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