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- W2536015087 abstract "Chimeric compounds combine the structural features of inhibitors of histone deacetylases (HDACi) and tyrosine kinase inhibitors (TKi), and therefore unite the effects of a dual-targeting strategy in one compound. Here, we describe the generation of such hybrid molecules. Small molecules, known as TKi, are combined with a Zn2+ chelating motive, preferentially a hydroxamic acid, in addition. The resulting small molecules also can inhibit histone deacetylases, which are dependent on the catalytically active Zn2+. Moreover, we summarize how the growth-inhibitory effects of these combined compounds can be determined with a simple proliferation assay with a leukemic cell line." @default.
- W2536015087 created "2016-10-28" @default.
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- W2536015087 date "2016-10-20" @default.
- W2536015087 modified "2023-09-23" @default.
- W2536015087 title "Generation and Assessment of Fusions Between HDACi and TKi" @default.
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- W2536015087 doi "https://doi.org/10.1007/978-1-4939-6527-4_31" @default.
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