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- W2536157095 abstract "Transforming growth factor-/spl beta/1 (TGF-/spl beta/1) is believed to be a key player in wound healing, promoting cell proliferation, migration, and matrix synthesis in a variety of cell types. We have designed two peptides, i.e., cytomodulin-1 (CM-1) and cytomodulin-2 (CM-2), to simulate the binding domain of TGF-/spl beta/1. In this study we examined the bioactivity of the two synthetic peptides CM-1 and CM-2 on human foreskin fibroblasts (HFF). Synthetic peptides CM-1 and CM-2 in culture media increased wound healing of fibroblasts in an injury model in vitro. In addition, CM-1 and CM-2 enhanced the gene expression of collagen I and increased the production of pro-collagen I peptide in HFF. These results suggest that CM-1 and CM-2 have potentially useful clinical applications in wound healing." @default.
- W2536157095 created "2016-10-28" @default.
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- W2536157095 date "2005-03-21" @default.
- W2536157095 modified "2023-10-16" @default.
- W2536157095 title "Synthetic peptides cytomodulin-1 (CM-1) and cytomodulin-2 (CM-2) promote collagen synthesis and wound healing in vitro" @default.
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- W2536157095 doi "https://doi.org/10.1109/iembs.2004.1404389" @default.
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