Matches in SemOpenAlex for { <https://semopenalex.org/work/W2536183792> ?p ?o ?g. }
Showing items 1 to 74 of
74
with 100 items per page.
- W2536183792 abstract "Mild cognitive impairment (MCI) is the earliest detectable transition state between normal aging and Alzheimer’s disease (AD). Recent case-control studies demonstrate that activity of the dorsal striatum, implicated in dopamine supply and transmission, is disrupted early in MCI relative to healthy counterparts (HC). However, there is little information about if, or how striatial dysfunction is related to AD pathobiology or cognitive capacity. Two-year resting-state fMRI data were available in 15 HC and 20 MCI older adults from the Alzheimer’s Disease Neuroimaging Initiative (ADNI) database. We analyzed the amplitude of low-frequency fluctuations (ALFF) and fractional ALFF (fALFF) in three frequency bands (typical bands: 0.01-0.08 Hz, slow-4: 0.027–0.073 Hz and slow-5: 0.01–0.027 Hz). We obtained measures of cognitive performance and cerebrospinal fluid levels of tau, ptau, and β-amyloid from the baseline visit. ALFF and fALFF of bilateral putamen, but not caudate, declined significantly in MCI group compared to the HC group, especially for slow-4 band. Controlling for age and diagnosis, higher baseline tau and ptau significantly predicted greater 2-year decline of ALFF (especially for slow-4) in the right putamen, while poorer baseline cognitive measures significantly predicted greater decline of fALFF in the left putamen. Putamen function declines early in the AD neurodegenerative process. Putaminal ALFF or fALFF may be a sensitive early index of AD pathobiology regardless of clinical diagnosis." @default.
- W2536183792 created "2016-10-28" @default.
- W2536183792 creator A5033585095 @default.
- W2536183792 creator A5051371795 @default.
- W2536183792 creator A5081303009 @default.
- W2536183792 creator A5087739494 @default.
- W2536183792 creator A5088720760 @default.
- W2536183792 date "2016-07-01" @default.
- W2536183792 modified "2023-09-27" @default.
- W2536183792 title "P4-209: Longitudinal Functional Decline of Striatum in Mild Cognitive Impairment" @default.
- W2536183792 doi "https://doi.org/10.1016/j.jalz.2016.06.2301" @default.
- W2536183792 hasPublicationYear "2016" @default.
- W2536183792 type Work @default.
- W2536183792 sameAs 2536183792 @default.
- W2536183792 citedByCount "0" @default.
- W2536183792 crossrefType "journal-article" @default.
- W2536183792 hasAuthorship W2536183792A5033585095 @default.
- W2536183792 hasAuthorship W2536183792A5051371795 @default.
- W2536183792 hasAuthorship W2536183792A5081303009 @default.
- W2536183792 hasAuthorship W2536183792A5087739494 @default.
- W2536183792 hasAuthorship W2536183792A5088720760 @default.
- W2536183792 hasConcept C118552586 @default.
- W2536183792 hasConcept C126322002 @default.
- W2536183792 hasConcept C15744967 @default.
- W2536183792 hasConcept C164705383 @default.
- W2536183792 hasConcept C169760540 @default.
- W2536183792 hasConcept C169900460 @default.
- W2536183792 hasConcept C2779134260 @default.
- W2536183792 hasConcept C2779483572 @default.
- W2536183792 hasConcept C2779714222 @default.
- W2536183792 hasConcept C2780062018 @default.
- W2536183792 hasConcept C2984863031 @default.
- W2536183792 hasConcept C2984915365 @default.
- W2536183792 hasConcept C513476851 @default.
- W2536183792 hasConcept C548259974 @default.
- W2536183792 hasConcept C58693492 @default.
- W2536183792 hasConcept C66324658 @default.
- W2536183792 hasConcept C71924100 @default.
- W2536183792 hasConceptScore W2536183792C118552586 @default.
- W2536183792 hasConceptScore W2536183792C126322002 @default.
- W2536183792 hasConceptScore W2536183792C15744967 @default.
- W2536183792 hasConceptScore W2536183792C164705383 @default.
- W2536183792 hasConceptScore W2536183792C169760540 @default.
- W2536183792 hasConceptScore W2536183792C169900460 @default.
- W2536183792 hasConceptScore W2536183792C2779134260 @default.
- W2536183792 hasConceptScore W2536183792C2779483572 @default.
- W2536183792 hasConceptScore W2536183792C2779714222 @default.
- W2536183792 hasConceptScore W2536183792C2780062018 @default.
- W2536183792 hasConceptScore W2536183792C2984863031 @default.
- W2536183792 hasConceptScore W2536183792C2984915365 @default.
- W2536183792 hasConceptScore W2536183792C513476851 @default.
- W2536183792 hasConceptScore W2536183792C548259974 @default.
- W2536183792 hasConceptScore W2536183792C58693492 @default.
- W2536183792 hasConceptScore W2536183792C66324658 @default.
- W2536183792 hasConceptScore W2536183792C71924100 @default.
- W2536183792 hasIssue "7S_Part_23" @default.
- W2536183792 hasLocation W25361837921 @default.
- W2536183792 hasOpenAccess W2536183792 @default.
- W2536183792 hasPrimaryLocation W25361837921 @default.
- W2536183792 hasRelatedWork W182016951 @default.
- W2536183792 hasRelatedWork W1971464738 @default.
- W2536183792 hasRelatedWork W2009341243 @default.
- W2536183792 hasRelatedWork W2077992747 @default.
- W2536183792 hasRelatedWork W2084114412 @default.
- W2536183792 hasRelatedWork W2123371569 @default.
- W2536183792 hasRelatedWork W2561267217 @default.
- W2536183792 hasRelatedWork W3089058906 @default.
- W2536183792 hasRelatedWork W4312341647 @default.
- W2536183792 hasRelatedWork W4312389194 @default.
- W2536183792 hasVolume "12" @default.
- W2536183792 isParatext "false" @default.
- W2536183792 isRetracted "false" @default.
- W2536183792 magId "2536183792" @default.
- W2536183792 workType "article" @default.