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• W2536213055 abstract "ABSTRACT Definition of the key parameters mediating effective antibody blocking of HIV-1 acquisition within mucosal tissue may prove critical to effective vaccine development and the prophylactic use of monoclonal antibodies. Although direct antibody-mediated neutralization is highly effective against cell-free virus, antibodies targeting different sites of envelope vulnerability may display differential activity against mucosal infection. Nonneutralizing antibodies (nnAbs) may also impact mucosal transmission events through Fc-gamma receptor (FcγR)-mediated inhibition. In this study, a panel of broadly neutralizing antibodies (bnAbs) and nnAbs, including those associated with protection in the RV144 vaccine trial, were screened for the ability to block HIV-1 acquisition and replication across a range of cellular and mucosal tissue models. Neutralization potency, as determined by the TZM-bl infection assay, did not fully predict activity in mucosal tissue. CD4-binding site (CD4bs)-specific bnAbs, in particular VRC01, were consistent in blocking HIV-1 infection across all cellular and tissue models. Membrane-proximal external region (MPER) (2F5) and outer domain glycan (2G12) bnAbs were also efficient in preventing infection of mucosal tissues, while the protective efficacy of bnAbs targeting V1-V2 glycans (PG9 and PG16) was more variable. In contrast, nnAbs alone and in combinations, while active in a range of cellular assays, were poorly protective against HIV-1 infection of mucosal tissues. These data suggest that tissue resident effector cell numbers and low FcγR expression may limit the potential of nnAbs to prevent establishment of the initial foci of infection. The solid protection provided by specific bnAbs clearly demonstrates their superior potential over that of nonneutralizing antibodies for preventing HIV-1 infection at the mucosal portals of infection. IMPORTANCE Key parameters mediating effective antibody blocking of HIV-1 acquisition within mucosal tissue have not been defined. While bnAbs are highly effective against cell-free virus, they are not induced by current vaccine candidates. However, nnAbs, readily induced by vaccines, can trigger antibody-dependent cellular effector functions, through engagement of their Fc-gamma receptors. Fc-mediated antiviral activity has been implicated as a secondary correlate of decreased HIV-1 risk in the RV144 vaccine efficacy trial, suggesting that protection might be mediated in the absence of classical neutralization. To aid vaccine design and selection of antibodies for use in passive protection strategies, we assessed a range of bnAbs and nnAbs for their potential to block ex vivo challenge of mucosal tissues. Our data clearly indicate the superior efficacy of neutralizing antibodies in preventing mucosal acquisition of infection. These results underscore the importance of maintaining the central focus of HIV-1 vaccine research on the induction of potently neutralizing antibodies." @default.
• W2536213055 created "2016-10-28" @default.
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• W2536213055 date "2017-01-01" @default.
• W2536213055 modified "2023-10-18" @default.
• W2536213055 title "Broadly Neutralizing Antibodies Display Potential for Prevention of HIV-1 Infection of Mucosal Tissue Superior to That of Nonneutralizing Antibodies" @default.
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• W2536213055 cites W1554980524 @default.
• W2536213055 cites W1623081601 @default.
• W2536213055 cites W1694178022 @default.
• W2536213055 cites W1908145173 @default.
• W2536213055 cites W1963807652 @default.
• W2536213055 cites W1974368619 @default.
• W2536213055 cites W1984645508 @default.
• W2536213055 cites W1990745725 @default.
• W2536213055 cites W1991656907 @default.
• W2536213055 cites W1993675648 @default.
• W2536213055 cites W1994744932 @default.
• W2536213055 cites W2011984976 @default.
• W2536213055 cites W2012923599 @default.
• W2536213055 cites W2013373526 @default.
• W2536213055 cites W2019405644 @default.
• W2536213055 cites W2030129290 @default.
• W2536213055 cites W2042408011 @default.
• W2536213055 cites W2053452332 @default.
• W2536213055 cites W2060119188 @default.
• W2536213055 cites W2069973240 @default.
• W2536213055 cites W2071959434 @default.
• W2536213055 cites W2078489697 @default.
• W2536213055 cites W2083002978 @default.
• W2536213055 cites W2083726777 @default.
• W2536213055 cites W2093961711 @default.
• W2536213055 cites W2094750078 @default.
• W2536213055 cites W2098013141 @default.
• W2536213055 cites W2102221920 @default.
• W2536213055 cites W2102949556 @default.
• W2536213055 cites W2108823547 @default.
• W2536213055 cites W2110233649 @default.
• W2536213055 cites W2116615247 @default.
• W2536213055 cites W2118489929 @default.
• W2536213055 cites W2124935744 @default.
• W2536213055 cites W2127424905 @default.
• W2536213055 cites W2128069859 @default.
• W2536213055 cites W2131896393 @default.
• W2536213055 cites W2133367683 @default.
• W2536213055 cites W2134206256 @default.
• W2536213055 cites W2134803208 @default.
• W2536213055 cites W2136489732 @default.
• W2536213055 cites W2137990592 @default.
• W2536213055 cites W2143421242 @default.
• W2536213055 cites W2143942902 @default.
• W2536213055 cites W2149317992 @default.
• W2536213055 cites W2152048324 @default.
• W2536213055 cites W2152314372 @default.
• W2536213055 cites W2152433082 @default.
• W2536213055 cites W2156818736 @default.
• W2536213055 cites W2158439602 @default.
• W2536213055 cites W2160742725 @default.
• W2536213055 cites W2164119431 @default.
• W2536213055 cites W2176236970 @default.
• W2536213055 cites W2190901406 @default.
• W2536213055 cites W2280540363 @default.
• W2536213055 cites W2321273585 @default.
• W2536213055 cites W2324986103 @default.
• W2536213055 cites W2336017858 @default.
• W2536213055 cites W2342613178 @default.
• W2536213055 cites W2343368748 @default.
• W2536213055 cites W2343862396 @default.
• W2536213055 cites W2359605300 @default.
• W2536213055 cites W2460321387 @default.
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• W2536213055 doi "https://doi.org/10.1128/jvi.01762-16" @default.
• W2536213055 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5165208" @default.
• W2536213055 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27795431" @default.
• W2536213055 hasPublicationYear "2017" @default.
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