Matches in SemOpenAlex for { <https://semopenalex.org/work/W2536297730> ?p ?o ?g. }
- W2536297730 abstract "Selective reuptake inhibitors (SSRIs), such as fluoxetine and sertraline, increase circulating Transforming-Growth-Factor-β1 (TGF-β1) levels in depressed patients, and are currently studied for their neuroprotective properties in Alzheimer's disease. TGF-β1 is an anti-inflammatory cytokine that exerts neuroprotective effects against β-amyloid (Aβ)-induced neurodegeneration. In the present work, the SSRI, fluoxetine, was tested for the ability to protect cortical neurons against 1 μM oligomeric Aβ1-42-induced toxicity. At therapeutic concentrations (100 nM-1 μM), fluoxetine significantly prevented Aβ-induced toxicity in mixed glia-neuronal cultures, but not in pure neuronal cultures. Though to a lesser extent, also sertraline was neuroprotective in mixed cultures, whereas serotonin (10 nM-10 μM) did not mimick fluoxetine effects. Glia-conditioned medium collected from astrocytes challenged with fluoxetine protected pure cortical neurons against Aβ toxicity. The effect was lost in the presence of a neutralizing antibody against TGF-β1 in the conditioned medium, or when the specific inhibitor of type-1 TGF-β1 receptor, SB431542, was added to pure neuronal cultures. Accordingly, a 24 h treatment of cortical astrocytes with fluoxetine promoted the release of active TGF-β1 in the culture media through the conversion of latent TGF-β1 to mature TGF-β1. Unlike fluoxetine, both serotonin and sertraline did not stimulate the astrocyte release of active TGF-β1. We conclude that fluoxetine is neuroprotective against Aβ toxicity via a paracrine signaling mediated by TGF-β1, which does not result from a simplistic SERT blockade." @default.
- W2536297730 created "2016-10-28" @default.
- W2536297730 creator A5011127299 @default.
- W2536297730 creator A5026906709 @default.
- W2536297730 creator A5041114001 @default.
- W2536297730 creator A5045739226 @default.
- W2536297730 creator A5054060868 @default.
- W2536297730 creator A5054803296 @default.
- W2536297730 creator A5056468131 @default.
- W2536297730 creator A5062403608 @default.
- W2536297730 creator A5068147978 @default.
- W2536297730 creator A5070147603 @default.
- W2536297730 creator A5082099245 @default.
- W2536297730 creator A5086290519 @default.
- W2536297730 date "2016-10-25" @default.
- W2536297730 modified "2023-10-17" @default.
- W2536297730 title "Fluoxetine Prevents Aβ1-42-Induced Toxicity via a Paracrine Signaling Mediated by Transforming-Growth-Factor-β1" @default.
- W2536297730 cites W1575754639 @default.
- W2536297730 cites W1582623884 @default.
- W2536297730 cites W1598371539 @default.
- W2536297730 cites W1888722399 @default.
- W2536297730 cites W1906855128 @default.
- W2536297730 cites W1939092506 @default.
- W2536297730 cites W1977085392 @default.
- W2536297730 cites W1979498073 @default.
- W2536297730 cites W1981542431 @default.
- W2536297730 cites W1987307065 @default.
- W2536297730 cites W1991988242 @default.
- W2536297730 cites W1992410941 @default.
- W2536297730 cites W1997626570 @default.
- W2536297730 cites W1998520631 @default.
- W2536297730 cites W2003127863 @default.
- W2536297730 cites W2013146608 @default.
- W2536297730 cites W2015172698 @default.
- W2536297730 cites W2015913347 @default.
- W2536297730 cites W2019640842 @default.
- W2536297730 cites W2022637707 @default.
- W2536297730 cites W2038304336 @default.
- W2536297730 cites W2040721710 @default.
- W2536297730 cites W2041320073 @default.
- W2536297730 cites W2049132525 @default.
- W2536297730 cites W2051240154 @default.
- W2536297730 cites W2052330193 @default.
- W2536297730 cites W2057342851 @default.
- W2536297730 cites W2062917074 @default.
- W2536297730 cites W2064359602 @default.
- W2536297730 cites W2065713557 @default.
- W2536297730 cites W2065843361 @default.
- W2536297730 cites W2073365413 @default.
- W2536297730 cites W2074125037 @default.
- W2536297730 cites W2076296680 @default.
- W2536297730 cites W2082429191 @default.
- W2536297730 cites W2082618148 @default.
- W2536297730 cites W2089644973 @default.
- W2536297730 cites W2090530943 @default.
- W2536297730 cites W2090763251 @default.
- W2536297730 cites W2091027054 @default.
- W2536297730 cites W2103578985 @default.
- W2536297730 cites W2103784702 @default.
- W2536297730 cites W2105683352 @default.
- W2536297730 cites W2115090099 @default.
- W2536297730 cites W2119210693 @default.
- W2536297730 cites W2127700980 @default.
- W2536297730 cites W2133797693 @default.
- W2536297730 cites W2137967937 @default.
- W2536297730 cites W2141096613 @default.
- W2536297730 cites W2148401297 @default.
- W2536297730 cites W2148854950 @default.
- W2536297730 cites W2152891102 @default.
- W2536297730 cites W2153849787 @default.
- W2536297730 cites W2161964141 @default.
- W2536297730 cites W2166070786 @default.
- W2536297730 cites W2180749160 @default.
- W2536297730 cites W2191889272 @default.
- W2536297730 cites W2223353695 @default.
- W2536297730 cites W2243723775 @default.
- W2536297730 cites W2252829763 @default.
- W2536297730 cites W2303485966 @default.
- W2536297730 cites W2329336071 @default.
- W2536297730 cites W2394910669 @default.
- W2536297730 cites W2418492450 @default.
- W2536297730 cites W2466094136 @default.
- W2536297730 cites W491163643 @default.
- W2536297730 doi "https://doi.org/10.3389/fphar.2016.00389" @default.
- W2536297730 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5078904" @default.
- W2536297730 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27826242" @default.
- W2536297730 hasPublicationYear "2016" @default.
- W2536297730 type Work @default.
- W2536297730 sameAs 2536297730 @default.
- W2536297730 citedByCount "38" @default.
- W2536297730 countsByYear W25362977302017 @default.
- W2536297730 countsByYear W25362977302018 @default.
- W2536297730 countsByYear W25362977302019 @default.
- W2536297730 countsByYear W25362977302020 @default.
- W2536297730 countsByYear W25362977302021 @default.
- W2536297730 countsByYear W25362977302022 @default.
- W2536297730 countsByYear W25362977302023 @default.
- W2536297730 crossrefType "journal-article" @default.
- W2536297730 hasAuthorship W2536297730A5011127299 @default.
- W2536297730 hasAuthorship W2536297730A5026906709 @default.