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- W2536307593 abstract "Influenza virus RNA polymerase is composed of three viral P proteins (PB1, PB2 and PA) and involved in both transcription and replication of the viral RNA genome. Using recombinant baculoviruses, we constructed the PA-PB1-PB2 (3P) complex and two kinds of 2P complex (PA-PB1 and PB1-PB2). The 3P complex is not fully active but vRNA acts as RNA effector for its conversion into an active form. The cap structure ( <sup xmlns:mml=http://www.w3.org/1998/Math/MathML xmlns:xlink=http://www.w3.org/1999/xlink>7</sup> mGpppAm) also plays an allosteric effector for RNA polymerase activation. The PB1-PB2 complex carries the catalytic specificity of transcriptase, while the PA-PB1 complex harbors the replicase specificity. We propose that the 3P and PB1-PB2 complexes behave as the transcriptase whereas the PA-PB1 complex has the specificity of replicase. A host factor(s) seems to be involved in the functional conversion of 3P complex. The candidate host factors have been isolated using yeast two-hybrid screening" @default.
- W2536307593 created "2016-10-28" @default.
- W2536307593 creator A5000215938 @default.
- W2536307593 date "2006-02-15" @default.
- W2536307593 modified "2023-09-22" @default.
- W2536307593 title "Control of influenza virus growth by cellular proteins" @default.
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- W2536307593 doi "https://doi.org/10.1109/mhs.2005.1589983" @default.
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