FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2536314894> ?p ?o ?g. }

• W2536314894 endingPage "247" @default.
• W2536314894 startingPage "247" @default.
• W2536314894 abstract "Context: The audiological features and cochlear morphology of individuals with noise-induced hearing loss (NIHL) are well characterized. However, the molecular processes in the cochlea are not well understood. Aims: To explore the role of the endoplasmic reticulum stress (ERS) response in the guinea pig model of cochlear damage induced by exposure to intense noise. Settings and Design: A pilot case–control study. Subjects and Methods: Forty-eight guinea pigs were divided into four equal groups. At 1, 4, or 14 days (d) post-exposure, the auditory brainstem responses (ABRs) were tested before sacrificing the subjects. The expression levels of the binding immunoglobulin protein/glucose-regulated protein 78 (BiP/GRP78) and C/EBP-homologous protein/growth arrest and DNA damage-inducible gene 153 (CHOP/Gadd153) proteins were evaluated using immunohistochemistry and Western blotting. The number of cochlear hair cells with altered nuclei was counted using confocal fluorescence microscopy. Statistical analysis used: One-way analysis of variance (ANOVA) and the least squares difference (LSD) test. Results: The outer hair cells (OHCs) showed changes of apoptosis, necrosis, and loss after noise exposure. In the 1- and 4-d groups, more apoptotic cells were found than necrotic cells (P < 0.01). The level of BiP/GRP78 was significantly higher in all three experimental groups compared to the control group (P < 0.01). The level of CHOP/Gadd153 was increased at 1 d post-exposure, achieving a peak that was maintained until 4 d, after which it returned to baseline levels by 14 d post-exposure. Conclusions: ERS response was activated by inducing the expression of BiP/GRP78 to lessen the extent of the resulting cellular damage and activating the CHOP/Gadd153 pathway to eliminate the most severely damaged cells." @default.
• W2536314894 created "2016-10-28" @default.
• W2536314894 creator A5000594791 @default.
• W2536314894 creator A5000812132 @default.
• W2536314894 creator A5022713992 @default.
• W2536314894 creator A5054474943 @default.
• W2536314894 creator A5057011805 @default.
• W2536314894 creator A5070053955 @default.
• W2536314894 date "2016-01-01" @default.
• W2536314894 modified "2023-10-10" @default.
• W2536314894 title "The Protective effect of the endoplasmic reticulum stress-related factors BiP/GRP78 and CHOP/Gadd153 on noise-induced hearing loss in guinea pigs" @default.
• W2536314894 cites W2016474922 @default.
• W2536314894 cites W2025511820 @default.
• W2536314894 cites W2035105931 @default.
• W2536314894 cites W2065521661 @default.
• W2536314894 cites W2072339970 @default.
• W2536314894 cites W2078310745 @default.
• W2536314894 cites W2085933321 @default.
• W2536314894 cites W2104790095 @default.
• W2536314894 cites W2134661135 @default.
• W2536314894 cites W2144303060 @default.
• W2536314894 cites W2149721868 @default.
• W2536314894 cites W2153074213 @default.
• W2536314894 cites W2166924755 @default.
• W2536314894 cites W2169199966 @default.
• W2536314894 cites W2422920576 @default.
• W2536314894 doi "https://doi.org/10.4103/1463-1741.192481" @default.
• W2536314894 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5187652" @default.
• W2536314894 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27762253" @default.
• W2536314894 hasPublicationYear "2016" @default.
• W2536314894 type Work @default.
• W2536314894 sameAs 2536314894 @default.
• W2536314894 citedByCount "19" @default.
• W2536314894 countsByYear W25363148942017 @default.
• W2536314894 countsByYear W25363148942018 @default.
• W2536314894 countsByYear W25363148942019 @default.
• W2536314894 countsByYear W25363148942020 @default.
• W2536314894 countsByYear W25363148942021 @default.
• W2536314894 countsByYear W25363148942022 @default.
• W2536314894 countsByYear W25363148942023 @default.
• W2536314894 crossrefType "journal-article" @default.
• W2536314894 hasAuthorship W2536314894A5000594791 @default.
• W2536314894 hasAuthorship W2536314894A5000812132 @default.
• W2536314894 hasAuthorship W2536314894A5022713992 @default.
• W2536314894 hasAuthorship W2536314894A5054474943 @default.
• W2536314894 hasAuthorship W2536314894A5057011805 @default.
• W2536314894 hasAuthorship W2536314894A5070053955 @default.
• W2536314894 hasBestOaLocation W25363148941 @default.
• W2536314894 hasConcept C104317684 @default.
• W2536314894 hasConcept C105702510 @default.
• W2536314894 hasConcept C126322002 @default.
• W2536314894 hasConcept C139447449 @default.
• W2536314894 hasConcept C142724271 @default.
• W2536314894 hasConcept C158617107 @default.
• W2536314894 hasConcept C16685009 @default.
• W2536314894 hasConcept C190283241 @default.
• W2536314894 hasConcept C203014093 @default.
• W2536314894 hasConcept C204232928 @default.
• W2536314894 hasConcept C2778585322 @default.
• W2536314894 hasConcept C2779356876 @default.
• W2536314894 hasConcept C2779725641 @default.
• W2536314894 hasConcept C2780130748 @default.
• W2536314894 hasConcept C2780493683 @default.
• W2536314894 hasConcept C2780659331 @default.
• W2536314894 hasConcept C2780898785 @default.
• W2536314894 hasConcept C3018332767 @default.
• W2536314894 hasConcept C4224716 @default.
• W2536314894 hasConcept C43791021 @default.
• W2536314894 hasConcept C54355233 @default.
• W2536314894 hasConcept C548259974 @default.
• W2536314894 hasConcept C71924100 @default.
• W2536314894 hasConcept C85265743 @default.
• W2536314894 hasConcept C86803240 @default.
• W2536314894 hasConcept C95444343 @default.
• W2536314894 hasConceptScore W2536314894C104317684 @default.
• W2536314894 hasConceptScore W2536314894C105702510 @default.
• W2536314894 hasConceptScore W2536314894C126322002 @default.
• W2536314894 hasConceptScore W2536314894C139447449 @default.
• W2536314894 hasConceptScore W2536314894C142724271 @default.
• W2536314894 hasConceptScore W2536314894C158617107 @default.
• W2536314894 hasConceptScore W2536314894C16685009 @default.
• W2536314894 hasConceptScore W2536314894C190283241 @default.
• W2536314894 hasConceptScore W2536314894C203014093 @default.
• W2536314894 hasConceptScore W2536314894C204232928 @default.
• W2536314894 hasConceptScore W2536314894C2778585322 @default.
• W2536314894 hasConceptScore W2536314894C2779356876 @default.
• W2536314894 hasConceptScore W2536314894C2779725641 @default.
• W2536314894 hasConceptScore W2536314894C2780130748 @default.
• W2536314894 hasConceptScore W2536314894C2780493683 @default.
• W2536314894 hasConceptScore W2536314894C2780659331 @default.
• W2536314894 hasConceptScore W2536314894C2780898785 @default.
• W2536314894 hasConceptScore W2536314894C3018332767 @default.
• W2536314894 hasConceptScore W2536314894C4224716 @default.
• W2536314894 hasConceptScore W2536314894C43791021 @default.
• W2536314894 hasConceptScore W2536314894C54355233 @default.
• W2536314894 hasConceptScore W2536314894C548259974 @default.
• W2536314894 hasConceptScore W2536314894C71924100 @default.
• W2536314894 hasConceptScore W2536314894C85265743 @default.

• next