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- W2536437371 abstract "A water-soluble derivative of nordihydroguaiaretic acid (NDGA, 1) was synthesized by coupling NDGA with N, N-dimethylglycine in the presence of dicyclohexylcarbodiimide and dimethylaminopyridine in CH2Cl2.The coupled product was further treated with HCl (g) to form tetraglycinylated NDGA 4 . HCl(G4N, 2) with 87% yield. Use of the fluorescence and the UV techniques in combination provided the apparent binding constants of G4N with WTabDNA as 5.05 X 100000 M-1 and with C98ab DNA as 8.23 X 100000 M-1, and with CT DNA as 1.31 X 1000000 M-1. Under acidic conditions, G4N showed greater binding ability. Results from experiments and computations indicate that G4N could function as a DNA major groove binder." @default.
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- W2536437371 date "2002-12-01" @default.
- W2536437371 modified "2023-09-23" @default.
- W2536437371 title "Design, Synthesis, and Binding Studies of Highly Water Soulble Nordihydroguaiaretic Acid Derivatives : a DNA Major Groove Binder" @default.
- W2536437371 doi "https://doi.org/10.30047/jgmb.200212.0003" @default.
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