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• W2536472446 abstract "The extent to which experience with a test influences performance is important in clinical and research settings. CogState and NIH Toolbox-Cognitive computerized batteries have not been studied extensively for practice effects, particularly in African Americans with mild cognitive impairment (MCI). We report here a preliminary study of repeat computerized testing in a community-based sample of African Americans. Participants were 28 African Americans (86% female; age range=65-87, M=73±6.0; MMSE range=25-30) recruited from Wayne State University Institute of Gerontology’s Healthier Black Elders Center and co-enrolled at the University of Michigan Alzheimer’s Disease Center. All participants received the National Alzheimer’s Coordinating Center’s Uniform Data Set assessment battery as part of a consensus conference evaluation, yielding a diagnosis of either normal (n=19) or MCI (n=7, Non-amnestic, predominantly multi-domain, executive dysfunction; n=2, Amnestic MCI). The prevalence of executive dysfunction may be related to the mixed MCI etiology in African Americans. Repeat computerized assessments with the CogState Brief Battery and NIH Toolbox-Cognitive Battery were administered within four months. There were no significant differences in age or education across groups. Repeated measures analyses examined differences in group performance across time. MCIs performed lower than controls across both assessments on two memory measures (Toolbox Picture Sequence Memory, p=.007; CogState One Card Learning, p=.016). Improvement across time, regardless of group, was seen for Toolbox Flanker Inhibitory Control and Attention (p=.004). A group/time interaction was shown for Toolbox Dimensional Change Card Sort (DCCS; p=.033) and List Sorting Working Memory (LSWM; p=.04). On DCCS, groups differed significantly at baseline, but MCIs improved to control levels at retest. On LSWM, there were no baseline differences, but controls improved significantly at retest, while MCIs did not. Overall, only the two memory measures consistently differentiated between controls and MCI over this short retest period, which is interesting given the predominance of non-amnestic MCI. Performance changes with prior exposure to a task were only evident on Toolbox, depending in part on the nature of the task (i.e., working memory, executive function) and diagnosis. In general, however, both computerized measures are readily adaptable to community settings and remain relatively consistent over time." @default.
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• W2536472446 date "2016-07-01" @default.
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• W2536472446 title "O3-03-04: Cogstate and NIH Toolbox-Cognitive Computerized Test Batteries: Repeat Assessments among African-American Elders" @default.
• W2536472446 doi "https://doi.org/10.1016/j.jalz.2016.06.521" @default.
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