FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2536497858> ?p ?o ?g. }

• W2536497858 endingPage "585.e8" @default.
• W2536497858 startingPage "571" @default.
• W2536497858 abstract "Nonalcoholic fatty liver disease (NAFLD) is associated with increased risk of hepatic, cardiovascular, and metabolic diseases. High-protein diets, rich in methionine and branched chain amino acids (BCAAs), apparently reduce liver fat, but can induce insulin resistance. We investigated the effects of diets high in animal protein (AP) vs plant protein (PP), which differ in levels of methionine and BCAAs, in patients with type 2 diabetes and NAFLD. We examined levels of liver fat, lipogenic indices, markers of inflammation, serum levels of fibroblast growth factor 21 (FGF21), and activation of signaling pathways in adipose tissue.We performed a prospective study of individuals with type 2 diabetes and NAFLD at a tertiary medical center in Germany from June 2013 through March 2015. We analyzed data from 37 subjects placed on a diet high in AP (rich in meat and dairy foods; n = 18) or PP (mainly legume protein; n = 19) without calorie restriction for 6 weeks. The diets were isocaloric with the same macronutrient composition (30% protein, 40% carbohydrates, and 30% fat). Participants were examined at the start of the study and after the 6-week diet period for body mass index, body composition, hip circumference, resting energy expenditure, and respiratory quotient. Body fat and intrahepatic fat were detected by magnetic resonance imaging and spectroscopy, respectively. Levels of glucose, insulin, liver enzymes, and inflammation markers, as well as individual free fatty acids and free amino acids, were measured in collected blood samples. Hyperinsulinemic euglycemic clamps were performed to determine whole-body insulin sensitivity. Subcutaneous adipose tissue samples were collected and analyzed for gene expression patterns and phosphorylation of signaling proteins.Postprandial levels of BCAAs and methionine were significantly higher in subjects on the AP vs the PP diet. The AP and PP diets each reduced liver fat by 36%-48% within 6 weeks (for AP diet P = .0002; for PP diet P = .001). These reductions were unrelated to change in body weight, but correlated with down-regulation of lipolysis and lipogenic indices. Serum level of FGF21 decreased by 50% in each group (for AP diet P < .0002; for PP diet P < .0002); decrease in FGF21 correlated with loss of hepatic fat. In gene expression analyses of adipose tissue, expression of the FGF21 receptor cofactor β-klotho was associated with reduced expression of genes encoding lipolytic and lipogenic proteins. In patients on each diet, levels of hepatic enzymes and markers of inflammation decreased, insulin sensitivity increased, and serum level of keratin 18 decreased.In a prospective study of patients with type 2 diabetes, we found diets high in protein (either animal or plant) significantly reduced liver fat independently of body weight, and reduced markers of insulin resistance and hepatic necroinflammation. The diets appear to mediate these changes via lipolytic and lipogenic pathways in adipose tissue. Negative effects of BCAA or methionine were not detectable. FGF21 level appears to be a marker of metabolic improvement. ClinicalTrials.gov ID NCT02402985." @default.
• W2536497858 created "2016-10-28" @default.
• W2536497858 creator A5001547362 @default.
• W2536497858 creator A5009808192 @default.
• W2536497858 creator A5012254729 @default.
• W2536497858 creator A5020833990 @default.
• W2536497858 creator A5021276076 @default.
• W2536497858 creator A5022032933 @default.
• W2536497858 creator A5024388784 @default.
• W2536497858 creator A5028621975 @default.
• W2536497858 creator A5046366965 @default.
• W2536497858 creator A5053092036 @default.
• W2536497858 creator A5054999050 @default.
• W2536497858 creator A5059313089 @default.
• W2536497858 creator A5062808834 @default.
• W2536497858 creator A5073351502 @default.
• W2536497858 creator A5075211228 @default.
• W2536497858 creator A5080149439 @default.
• W2536497858 creator A5081622776 @default.
• W2536497858 creator A5082861333 @default.
• W2536497858 creator A5084639062 @default.
• W2536497858 date "2017-02-01" @default.
• W2536497858 modified "2023-10-10" @default.
• W2536497858 title "Isocaloric Diets High in Animal or Plant Protein Reduce Liver Fat and Inflammation in Individuals With Type 2 Diabetes" @default.
• W2536497858 cites W1598615410 @default.
• W2536497858 cites W1856151485 @default.
• W2536497858 cites W1908039135 @default.
• W2536497858 cites W1966482757 @default.
• W2536497858 cites W1975189993 @default.
• W2536497858 cites W1975388439 @default.
• W2536497858 cites W1976833226 @default.
• W2536497858 cites W1981894899 @default.
• W2536497858 cites W1992609861 @default.
• W2536497858 cites W1995726350 @default.
• W2536497858 cites W1998323589 @default.
• W2536497858 cites W2002364623 @default.
• W2536497858 cites W2005063766 @default.
• W2536497858 cites W2010895111 @default.
• W2536497858 cites W2011275709 @default.
• W2536497858 cites W2014160361 @default.
• W2536497858 cites W2017843740 @default.
• W2536497858 cites W2018735093 @default.
• W2536497858 cites W2020362927 @default.
• W2536497858 cites W2028034176 @default.
• W2536497858 cites W2028782957 @default.
• W2536497858 cites W2030908500 @default.
• W2536497858 cites W2031533316 @default.
• W2536497858 cites W2034531865 @default.
• W2536497858 cites W2036409621 @default.
• W2536497858 cites W2048578282 @default.
• W2536497858 cites W2058203033 @default.
• W2536497858 cites W2060607801 @default.
• W2536497858 cites W2071660471 @default.
• W2536497858 cites W2073171330 @default.
• W2536497858 cites W2078281362 @default.
• W2536497858 cites W2079195246 @default.
• W2536497858 cites W2079902915 @default.
• W2536497858 cites W2084934089 @default.
• W2536497858 cites W2094188965 @default.
• W2536497858 cites W2095898199 @default.
• W2536497858 cites W2095985521 @default.
• W2536497858 cites W2098667700 @default.
• W2536497858 cites W2099520889 @default.
• W2536497858 cites W2100788923 @default.
• W2536497858 cites W2102140685 @default.
• W2536497858 cites W2109371472 @default.
• W2536497858 cites W2112038959 @default.
• W2536497858 cites W2114737158 @default.
• W2536497858 cites W2120590794 @default.
• W2536497858 cites W2123908001 @default.
• W2536497858 cites W2126188293 @default.
• W2536497858 cites W2129570057 @default.
• W2536497858 cites W2131501155 @default.
• W2536497858 cites W2140467079 @default.
• W2536497858 cites W2141007767 @default.
• W2536497858 cites W2144702146 @default.
• W2536497858 cites W2147224974 @default.
• W2536497858 cites W2151405050 @default.
• W2536497858 cites W2155010729 @default.
• W2536497858 cites W2158061384 @default.
• W2536497858 cites W2159469729 @default.
• W2536497858 cites W2170065584 @default.
• W2536497858 cites W2170124267 @default.
• W2536497858 cites W2198244887 @default.
• W2536497858 cites W2201894846 @default.
• W2536497858 cites W2302624537 @default.
• W2536497858 doi "https://doi.org/10.1053/j.gastro.2016.10.007" @default.
• W2536497858 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27765690" @default.
• W2536497858 hasPublicationYear "2017" @default.
• W2536497858 type Work @default.
• W2536497858 sameAs 2536497858 @default.
• W2536497858 citedByCount "184" @default.
• W2536497858 countsByYear W25364978582017 @default.
• W2536497858 countsByYear W25364978582018 @default.
• W2536497858 countsByYear W25364978582019 @default.
• W2536497858 countsByYear W25364978582020 @default.
• W2536497858 countsByYear W25364978582021 @default.
• W2536497858 countsByYear W25364978582022 @default.

• next