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- W2536499886 abstract "Vascular and Alzheimer’s Dementia have been shown to be more common in patients with Diabetes Mellitus (DM). White matter changes (WMC) are documented to have association with ischemic strokes and DM. Vascular changes and micro-embolic strokes appear to contribute to WMC. Our Hypothesis is DM/Pre-DM lead to higher micro-embolic signal (MES) on Transcranial Doppler (TCD) more than other risk factors, thus accounting for higher WMC. Retrospective data analysis was performed on subjects. Factors analyzed included TCD findings to evaluate for MES, past medical history, previous medications, Basic Metabolic Index, HbA1c, other basic stroke labs, Echocardiography, Computer Tomography Angiography findings, Magnetic Resonance Imaging (MRI) findings, and National Institute of Health Stroke Scale. American Diabetes Association Criteria was used to determine DM (HbA1c ≥ 6.5%) and Pre-DM (HbA1c 5.7 – 6.4%). Five regions on MRI described by Wahlund et al. (Stroke, 2001) were evaluated. WMC on MRI were significant with hyper-intensities ≥ 5 mm on both T2 and FLAIR images. Lacunes and Basal Ganglia changes were significant with > 2 mm signal characteristics similar to cerebrospinal fluid. A single rater reviewed and rated images. 56 age-matched MES negative patients were selected and his/her MRIs were reviewed for comparison. MES positive patients who had co-existent atrial fibrillation were excluded in the final analysis. 36 of 760 total patients receiving TCD analysis were MES positive. 64% of MES positive patients had DM/Pre-DM (23/36). The mean WMC scale as determined by Wahlund et. al. was greater in the DM/pre-DM group. In the frontal and parieto-occipital regions, the WMC rating score increased 1.3 to 1.8 and 1.5 to 2.0, respectively. In the MES negative group, WMC were more often seen in the parieto-occipital region." @default.
- W2536499886 created "2016-10-28" @default.
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- W2536499886 date "2016-07-01" @default.
- W2536499886 modified "2023-09-27" @default.
- W2536499886 title "P3-288: Hyperglycemia: Predisposition for Microemboli, Stroke, and White Matter Changes" @default.
- W2536499886 doi "https://doi.org/10.1016/j.jalz.2016.06.1952" @default.
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