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- W2536558049 abstract "The visinin-like protein-1 (VILIP-1) was reported to be involved in neuronal calcium homeostasis and play a role as an useful indicator of neuronal injury. VILIP-1 have been also suggested as a prognostic factor to measure cognitive impairment in Alzheimer’s disease (AD) . Thus, the aim of our study was the evaluation of the diagnostic utility of cerebrospinal fluid (CSF) VILIP-1 levels in patients with Alzheimer’s disease and mild cognitive impairment (MCI) and to compare it with CSF concentrations of other AD biomarkers. VILIP-1, Aβ40, Aβ42, hTau i pTau were assayed in CSF of 20 carefully selected patients with a clinical diagnosis of AD, 15 patients with MCI and in 15 subjects without cognitive decline. Concentrations of the biomarkers were determined using ELISA method. The CSF levels of VILIP-1 were significantly higher in AD group (Median 138 pg/mL) in comparison with MCI subjects (Median 69 pg/mL) and cognitively normal group (Median 36 pg/mL). Elevated CSF VILIP-1 concentrations correlated with reduced Aβ42/40 ratio, increased CSF pTau concentrations and increased Erlangen score points. The results obtained in current study present a potential usefulness of VILIP-1 as a diagnostic factor of Alzheimer’s disease, but it requires further investigations on larger study group." @default.
- W2536558049 created "2016-10-28" @default.
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- W2536558049 date "2016-07-01" @default.
- W2536558049 modified "2023-10-17" @default.
- W2536558049 title "P4-107: Concentration of Visinin-Like Protein-1 (VILIP-1) in the Cerebrospinal Fluid of Patients with Alzheimer’s Disease and Mild Cognitive Impairment (MCI)" @default.
- W2536558049 doi "https://doi.org/10.1016/j.jalz.2016.06.2198" @default.
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