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- W2536584014 abstract "The Small GTPase ADP-ribosylation factor 6 (Arf6) functions as the molecular switch in cellular signaling pathways by cycling between GDP-bound inactive and GTP-bound active form, which is precisely regulated by two regulators, guanine nucleotide exchange factors (GEFs) and GTPase-activating proteins (GAPs). Numerous studies have shown that these machineries play critical roles in tumor angiogenesis/growth and cancer cell invasion/metastasis through regulating the cycling of Arf6. Here, we summarize accumulating knowledge for involvement of Arf6 GEFs/GAPs and small molecule inhibitors of Arf6 signaling/cycling in cancer progression, and discuss possible strategies for developing innovative anti-cancer drugs targeting Arf6 signaling/cycling." @default.
- W2536584014 created "2016-10-28" @default.
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- W2536584014 creator A5042371488 @default.
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- W2536584014 date "2017-01-01" @default.
- W2536584014 modified "2023-10-14" @default.
- W2536584014 title "Machineries regulating the activity of the small GTPase Arf6 in cancer cells are potential targets for developing innovative anti-cancer drugs" @default.
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- W2536584014 doi "https://doi.org/10.1016/j.jbior.2016.10.004" @default.
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