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• W2536622113 abstract "It is becoming increasingly important to investigate drug metabolites to evaluate their toxic or preventive effects after administration of the parent compound. In our previous study, isoliquiritigenin isolated from Glycyrrhizae Radix effectively protected mouse-derived hippocampal neuronal cells (HT22) against 5mM glutamate-induced oxidative stress. However, there is little information on the protective effects of the metabolites of isoliquiritigenin on HT22 cells. In this study, isoliquiritigenin and its Phase I metabolites were prepared and their neuroprotective activities on glutamate-treated HT22 cells were compared. The prepared metabolites were liquiritigenin (1), 2',4,4',5'-tetrahydroxychalcone (2), sulfuretin (3), butein (4), davidigenin (5), and cis-6,4'-dihydroxyaurone (6). Among the six metabolites, 4 showed better neuroprotective effects than the parent compound, isoliquiritigenin. Our study suggests that the neuroprotective effect of isoliquiritigenin could be elevated by its active metabolite 4, which is a chalcone containing a catechol group in the B ring." @default.
• W2536622113 created "2016-10-28" @default.
• W2536622113 creator A5005933828 @default.
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• W2536622113 date "2016-12-01" @default.
• W2536622113 modified "2023-10-13" @default.
• W2536622113 title "The comparison of neuroprotective effects of isoliquiritigenin and its Phase I metabolites against glutamate-induced HT22 cell death" @default.
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• W2536622113 doi "https://doi.org/10.1016/j.bmcl.2016.10.072" @default.
• W2536622113 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27815122" @default.
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