FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W253663331> ?p ?o ?g. }

• W253663331 endingPage "1690" @default.
• W253663331 startingPage "1686" @default.
• W253663331 abstract "Abstract A killing defect of natural killer (NK) cells in the absence of NK cytotoxic factors (NKCF) was first demonstrated in a child with Hodgkin's disease. The patient lacked detectable NK cell activity in every phase of the disease as measured by a four-hour 51Cr-release assay using K562 cells as a target. The percent lysis at a 40:1 effector:target ratio by the patient's lymphocytes was persistently below 0.3% as compared with the normal lymphocyte value of 46.2% +/- 5.8% (mean +/- SD). NK cell activity was not detectable at effector:target ratios of 10:1 to 80:1 and by prolongation of the incubation time, and the NK cell defect was not restored or improved by lymphocyte stimulation with polyinosinic-polycytidilic acid, interferon (IFN)-alpha, or interleukin 2 (IL 2). The numbers of Leu-7+ cells and Leu-11+ cells were normal as counted by flow cytometry. A single cell- in-agarose assay demonstrated normal numbers of target binding cells (TBCs), and they showed the morphology of “large granular lymphocytes.” However, there were no TBCs with dead targets. These results indicated that the patient's lymphocytes contained normal numbers of NK cells that were capable of recognizing and binding to a target but were incapable of killing the bound target cell. The patient's lymphocytes were then studied for their release of NKCF upon interaction with K562 cells. The patient's cells did not release NKCF, and the NK cell defect was not restored or improved by stimulation of the cells with IFN or IL 2. It is suggested that the deficient release of NKCF may have been related to the killing defect of the NK cells in this patient." @default.
• W253663331 created "2016-06-24" @default.
• W253663331 creator A5017960488 @default.
• W253663331 creator A5032856968 @default.
• W253663331 creator A5038295968 @default.
• W253663331 creator A5042947285 @default.
• W253663331 creator A5061148658 @default.
• W253663331 creator A5066824209 @default.
• W253663331 creator A5075020773 @default.
• W253663331 date "1987-06-01" @default.
• W253663331 modified "2023-09-29" @default.
• W253663331 title "A killing defect of natural killer cells with the absence of natural killer cytotoxic factors in a child with Hodgkin's disease" @default.
• W253663331 cites W1482320598 @default.
• W253663331 cites W1484112158 @default.
• W253663331 cites W1504875452 @default.
• W253663331 cites W1572106051 @default.
• W253663331 cites W1598448236 @default.
• W253663331 cites W1604871681 @default.
• W253663331 cites W1605216847 @default.
• W253663331 cites W1919244446 @default.
• W253663331 cites W1963779453 @default.
• W253663331 cites W1968461629 @default.
• W253663331 cites W2037554647 @default.
• W253663331 cites W2045964137 @default.
• W253663331 cites W2100673560 @default.
• W253663331 cites W2116996002 @default.
• W253663331 cites W2118605877 @default.
• W253663331 cites W2129829956 @default.
• W253663331 cites W2135110408 @default.
• W253663331 cites W2161082695 @default.
• W253663331 cites W2402553453 @default.
• W253663331 cites W2406041221 @default.
• W253663331 cites W2419032978 @default.
• W253663331 cites W1942538167 @default.
• W253663331 doi "https://doi.org/10.1182/blood.v69.6.1686.1686" @default.
• W253663331 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3580573" @default.
• W253663331 hasPublicationYear "1987" @default.
• W253663331 type Work @default.
• W253663331 sameAs 253663331 @default.
• W253663331 citedByCount "18" @default.
• W253663331 countsByYear W2536633312016 @default.
• W253663331 countsByYear W2536633312017 @default.
• W253663331 countsByYear W2536633312018 @default.
• W253663331 countsByYear W2536633312019 @default.
• W253663331 countsByYear W2536633312021 @default.
• W253663331 countsByYear W2536633312023 @default.
• W253663331 crossrefType "journal-article" @default.
• W253663331 hasAuthorship W253663331A5017960488 @default.
• W253663331 hasAuthorship W253663331A5032856968 @default.
• W253663331 hasAuthorship W253663331A5038295968 @default.
• W253663331 hasAuthorship W253663331A5042947285 @default.
• W253663331 hasAuthorship W253663331A5061148658 @default.
• W253663331 hasAuthorship W253663331A5066824209 @default.
• W253663331 hasAuthorship W253663331A5075020773 @default.
• W253663331 hasBestOaLocation W2536633311 @default.
• W253663331 hasConcept C129374314 @default.
• W253663331 hasConcept C1491633281 @default.
• W253663331 hasConcept C149532602 @default.
• W253663331 hasConcept C153911025 @default.
• W253663331 hasConcept C154317977 @default.
• W253663331 hasConcept C171122931 @default.
• W253663331 hasConcept C202751555 @default.
• W253663331 hasConcept C203014093 @default.
• W253663331 hasConcept C206191192 @default.
• W253663331 hasConcept C2776090121 @default.
• W253663331 hasConcept C2777761686 @default.
• W253663331 hasConcept C2778102761 @default.
• W253663331 hasConcept C2778461978 @default.
• W253663331 hasConcept C28651165 @default.
• W253663331 hasConcept C553184892 @default.
• W253663331 hasConcept C55493867 @default.
• W253663331 hasConcept C86803240 @default.
• W253663331 hasConcept C8891405 @default.
• W253663331 hasConceptScore W253663331C129374314 @default.
• W253663331 hasConceptScore W253663331C1491633281 @default.
• W253663331 hasConceptScore W253663331C149532602 @default.
• W253663331 hasConceptScore W253663331C153911025 @default.
• W253663331 hasConceptScore W253663331C154317977 @default.
• W253663331 hasConceptScore W253663331C171122931 @default.
• W253663331 hasConceptScore W253663331C202751555 @default.
• W253663331 hasConceptScore W253663331C203014093 @default.
• W253663331 hasConceptScore W253663331C206191192 @default.
• W253663331 hasConceptScore W253663331C2776090121 @default.
• W253663331 hasConceptScore W253663331C2777761686 @default.
• W253663331 hasConceptScore W253663331C2778102761 @default.
• W253663331 hasConceptScore W253663331C2778461978 @default.
• W253663331 hasConceptScore W253663331C28651165 @default.
• W253663331 hasConceptScore W253663331C553184892 @default.
• W253663331 hasConceptScore W253663331C55493867 @default.
• W253663331 hasConceptScore W253663331C86803240 @default.
• W253663331 hasConceptScore W253663331C8891405 @default.
• W253663331 hasIssue "6" @default.
• W253663331 hasLocation W2536633311 @default.
• W253663331 hasOpenAccess W253663331 @default.
• W253663331 hasPrimaryLocation W2536633311 @default.
• W253663331 hasRelatedWork W132117956 @default.
• W253663331 hasRelatedWork W1483170373 @default.
• W253663331 hasRelatedWork W1629874984 @default.

• next