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• W2536688740 abstract "Abstract Human beings are exposed to carcinogens through air, water, food and tobacco smoke. Nickel chloride (NiCl 2 ) is a toxic and carcinogenic environmental and occupational pollutant, which was previously classified as a non‐genotoxic carcinogen and thought to not directly alter the DNA . Non‐genotoxic carcinogens such as NiCl 2 are difficult to detect in vitro ; hence, a heavy reliance on animal studies exists. NiCl 2 has previously been classified as a non‐genotoxic carcinogen ( NGTC ); however, after studying the effect of NiCl 2 on many mechanistic end‐points, it has become clear that NiCl 2 behaves more like a genotoxic carcinogen. The induction of reactive oxygen species ( ROS ) after treatment with NiCl 2 along with positive micronuclei results from a preliminary 5‐day chronic dose micronucleus study further supports that NiCl 2 has been misclassified as a NGTC . It is possible that NiCl 2 causes indirect DNA damage by the production of ROS and requires a longer, chronic exposure, which is more similar to that of human exposure. The focus of this MiniReview is on research into the molecular mechanisms of nickel‐induced carcinogenicity and potential genotoxicity, with a focus on one of the salts of greatest commercial importance, nickel chloride." @default.
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• W2536688740 date "2016-12-22" @default.
• W2536688740 modified "2023-10-16" @default.
• W2536688740 title "Is Nickel Chloride really a Non‐Genotoxic Carcinogen?" @default.
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• W2536688740 doi "https://doi.org/10.1111/bcpt.12689" @default.
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