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- W2536691516 abstract "In Saccharomyces cerevisiae, after 8-methoxy- psoralen (8-(OMe)Ps) photoaddition, more crosslinks are induced per unit dose in mitochondrial'DNA than in nuclear DNA. In wild- type cells treated in the exponential phase of growth, single- and double-strand breaks are produced during crosslink removal and then are rejoined upon postexposure incubation. The incision step is almost blocked in the rad3-2 mutant, which is also defective in excision-repair of UV-induced (254 nm) pyrimidine dimers. The cutting of crosslinks from nuclear DNA.is depressed in wild-type stationary-phase cells. This is correlated with a higher sensitivity of such cells to 8-(OMe)Ps photoinduced cell killing. The incision of crosslinks is dramatically reduced in mitochondrial DNA. The rejoining of single- and double-strand breaks is not only dependent on the product of the RAD51 gene (as shown by others) but also of the PS02 gene. A correlation was found between the ability to recombine and strand rejoining. Therefore, as in bacteria, both the excision and the recombinational repair systems are involved in crosslink repair in yeast. However, double-strand breaks in yeast constitute repair intermediates which are not detected in Escherichia coli. The LD37 (dose necessary to induce a mean of one lethal hit per cell) corresponds to about 120 crosslinks per ge- nome in exponential-phase cells of the wild type and to 1-2 cross- links in the pso2-1 mutant. Strains. The normal haploid strain of S. cerevisiae N123 (a hisl) was used. The pso2-1 mutant derived from N123 is spe- cifically sensitive to photoaddition of psoralen derivatives (14). The excision-defective strains radl-3 and rad3-2 derived from strains N123 (E. Moustacchi) and LP194 (L. Prakash), re- spectively, were also used. These mutants are sensitive to 254- nm UV radiation and 8-(OMe)Ps photoaddition." @default.
- W2536691516 created "2016-10-28" @default.
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- W2536691516 date "2016-01-01" @default.
- W2536691516 modified "2023-09-27" @default.
- W2536691516 title "The fate of 8-methoxypsoralen pho and mitochondrial yeast DNA: Corr repair-deficient strains" @default.
- W2536691516 hasPublicationYear "2016" @default.
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