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- W2536701740 endingPage "1103" @default.
- W2536701740 startingPage "1087" @default.
- W2536701740 abstract "Alzheimer's disease (AD) is characterized by brain deposition of amyloid plaques and tau neurofibrillary tangles along with steady cognitive decline. Synaptic damage, an early pathological event, correlates strongly with cognitive deficits and memory loss. Mitochondria are essential organelles for synaptic function. Neurons utilize specialized mechanisms to drive mitochondrial trafficking to synapses in which mitochondria buffer Ca2+ and serve as local energy sources by supplying ATP to sustain neurotransmitter release. Mitochondrial abnormalities are one of the earliest and prominent features in AD patient brains. Amyloid-β (Aβ) and tau both trigger mitochondrial alterations. Accumulating evidence suggests that mitochondrial perturbation acts as a key factor that is involved in synaptic failure and degeneration in AD. The importance of mitochondria in supporting synaptic function has made them a promising target of new therapeutic strategies for AD. Here, we review the molecular mechanisms regulating mitochondrial function at synapses, highlight recent findings on the disturbance of mitochondrial dynamics and transport in AD, and discuss how these alterations impact synaptic vesicle release and thus contribute to synaptic pathology associated with AD." @default.
- W2536701740 created "2016-10-28" @default.
- W2536701740 creator A5018529320 @default.
- W2536701740 creator A5082810239 @default.
- W2536701740 date "2017-04-19" @default.
- W2536701740 modified "2023-10-18" @default.
- W2536701740 title "Mitochondrial Aspects of Synaptic Dysfunction in Alzheimer’s Disease" @default.
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