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- W2536703388 abstract "The aim of this study was to identify the chemical group, evaluate an acute toxicity study and analyze the effect of aqueous extract <i>Khaya senegalensis</i> (Meliaceae), on experimentally induced hyperglycemic condition in rats. The phytochemical study of the aqueous extract of <i>Khaya senegalensis</i> revealed the presence of active secondary metabolic compounds such as flavonoids, polyphenols, catechol tannins, quinones, saponins, sterols and terpenes. The stem bark of <i>Khaya senegalensis</i> was used for acute toxicity study by gavage in Swiss mice. The aqueous extract of <i>Khaya senegalensis</i> (AEKS) at the dose of 35±5 mg/kg administrated by gavage showed that all the mice treated were living after 24 hours. The lethal dose obtained by intraperitoneal administration with graded doses to the mice was 1778 mg/kg. This extract could be non-toxic. The study of AEKS activity on blood glucose in rats showed a significant (p <0.01) the concentration of glucose in the serum of the treated rats with the AEKS (96.2 ± 30 mg/dl) and Glibenclamide (92.4±10 mg/dL), compared to glucose concentrations in the serum of hyperglycemic rats (197.1 ± 50 mg/dl). Thus, the study showed hypoglycemic activity of aqueous extract of <i>Khaya senegalensis</i>. In conclusion, the administration of AEKS causes hypoglycemic activity in rats given oral glucose load. Hypoglycemia this is due to the presence of active chemical groups in the extract of this plant, such as flavonoids, catechin tannins, polyphenols, quinones, sterols and terpenes. These results confirm the therapeutic indication in traditional medicine <i>Khaya senegalensis</i> in the treatment of diabetic disease." @default.
- W2536703388 created "2016-10-28" @default.
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- W2536703388 date "2016-01-01" @default.
- W2536703388 modified "2023-10-17" @default.
- W2536703388 title "Antihyperglycemic Activity and Phytochemical Screening of <i>Khaya Senegalensis</i> (Meliaceae) in Wistar Rats" @default.
- W2536703388 doi "https://doi.org/10.11648/j.ab.20160405.11" @default.
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