Matches in SemOpenAlex for { <https://semopenalex.org/work/W2536767931> ?p ?o ?g. }
- W2536767931 endingPage "4435" @default.
- W2536767931 startingPage "4425" @default.
- W2536767931 abstract "Abstract West Nile virus (WNV) is a neurotropic ssRNA flavivirus that can cause encephalitis, meningitis, and death in humans and mice. Human TLR7 and TLR8 and mouse TLR7 recognize viral ssRNA motifs and induce antiviral immunity. However, the role of mouse TLR8 in antiviral immunity is poorly understood. In this article, we report that TLR8-deficient (Tlr8−/−) mice were resistant to WNV infection compared with wild-type controls. Efficient WNV clearance and moderate susceptibility to WNV-mediated neuronal death in Tlr8−/− mice were attributed to overexpression of Tlr7 and IFN-stimulated gene-56 expression, whereas reduced expression of the proapoptotic gene coding Bcl2-associated X protein was observed. Interestingly, suppressor of cytokine signaling (SOCS)-1 directly associated with TLR8, but not with TLR7, indicating a novel role for TLR8 regulation of SOCS-1 function, whereas selective small interfering RNA knockdown of Socs-1 resulted in induced IFN-stimulated gene-56 and Tlr7 expression following WNV infection. Collectively, we report that TLR8 coupling with SOCS-1 inhibits TLR7-mediated antiviral immunity during WNV infection in mice." @default.
- W2536767931 created "2016-10-28" @default.
- W2536767931 creator A5000422885 @default.
- W2536767931 creator A5000426744 @default.
- W2536767931 creator A5010060046 @default.
- W2536767931 creator A5016103801 @default.
- W2536767931 creator A5016366290 @default.
- W2536767931 creator A5022173812 @default.
- W2536767931 creator A5029652571 @default.
- W2536767931 creator A5029910445 @default.
- W2536767931 creator A5041881133 @default.
- W2536767931 creator A5072477603 @default.
- W2536767931 creator A5076059721 @default.
- W2536767931 date "2016-12-01" @default.
- W2536767931 modified "2023-10-16" @default.
- W2536767931 title "TLR8 Couples SOCS-1 and Restrains TLR7-Mediated Antiviral Immunity, Exacerbating West Nile Virus Infection in Mice" @default.
- W2536767931 cites W1502575492 @default.
- W2536767931 cites W1517210971 @default.
- W2536767931 cites W1574186694 @default.
- W2536767931 cites W1672838486 @default.
- W2536767931 cites W1909313221 @default.
- W2536767931 cites W1951507118 @default.
- W2536767931 cites W1964133468 @default.
- W2536767931 cites W1965228865 @default.
- W2536767931 cites W1965464733 @default.
- W2536767931 cites W1967575570 @default.
- W2536767931 cites W1968215930 @default.
- W2536767931 cites W1969072247 @default.
- W2536767931 cites W1969587116 @default.
- W2536767931 cites W1970432189 @default.
- W2536767931 cites W1971457453 @default.
- W2536767931 cites W1979328748 @default.
- W2536767931 cites W1981582579 @default.
- W2536767931 cites W1984760454 @default.
- W2536767931 cites W1986060457 @default.
- W2536767931 cites W1986186646 @default.
- W2536767931 cites W1991186601 @default.
- W2536767931 cites W1994942139 @default.
- W2536767931 cites W1995707767 @default.
- W2536767931 cites W2008720452 @default.
- W2536767931 cites W2011438792 @default.
- W2536767931 cites W2012628595 @default.
- W2536767931 cites W2014246321 @default.
- W2536767931 cites W2018722698 @default.
- W2536767931 cites W2020895935 @default.
- W2536767931 cites W2021655479 @default.
- W2536767931 cites W2027067857 @default.
- W2536767931 cites W2027977487 @default.
- W2536767931 cites W2028876212 @default.
- W2536767931 cites W2029881869 @default.
- W2536767931 cites W2034763496 @default.
- W2536767931 cites W2035509260 @default.
- W2536767931 cites W2039869672 @default.
- W2536767931 cites W2041517581 @default.
- W2536767931 cites W2047386963 @default.
- W2536767931 cites W2058756509 @default.
- W2536767931 cites W2060731298 @default.
- W2536767931 cites W2061460524 @default.
- W2536767931 cites W2063346783 @default.
- W2536767931 cites W2066878270 @default.
- W2536767931 cites W2069009387 @default.
- W2536767931 cites W2069394593 @default.
- W2536767931 cites W2075442260 @default.
- W2536767931 cites W2075908076 @default.
- W2536767931 cites W2076813673 @default.
- W2536767931 cites W2078811876 @default.
- W2536767931 cites W2079776221 @default.
- W2536767931 cites W2080287136 @default.
- W2536767931 cites W2082856293 @default.
- W2536767931 cites W2089077517 @default.
- W2536767931 cites W2092235636 @default.
- W2536767931 cites W2093813232 @default.
- W2536767931 cites W2097595072 @default.
- W2536767931 cites W2099540110 @default.
- W2536767931 cites W2100145845 @default.
- W2536767931 cites W2100663201 @default.
- W2536767931 cites W2101006270 @default.
- W2536767931 cites W2101135115 @default.
- W2536767931 cites W2106212645 @default.
- W2536767931 cites W2111379723 @default.
- W2536767931 cites W2115469277 @default.
- W2536767931 cites W2116787729 @default.
- W2536767931 cites W2119791199 @default.
- W2536767931 cites W2120229808 @default.
- W2536767931 cites W2126393987 @default.
- W2536767931 cites W2134119588 @default.
- W2536767931 cites W2135107639 @default.
- W2536767931 cites W2136052329 @default.
- W2536767931 cites W2136947275 @default.
- W2536767931 cites W2139993955 @default.
- W2536767931 cites W2141659272 @default.
- W2536767931 cites W2143632210 @default.
- W2536767931 cites W2148937272 @default.
- W2536767931 cites W2151943479 @default.
- W2536767931 cites W2152362116 @default.
- W2536767931 cites W2153342952 @default.
- W2536767931 cites W2155589041 @default.
- W2536767931 cites W2157810587 @default.