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- W2536832698 abstract "The focus of the chapter is the analysis of protein acetylation and using mass spectrometry (MS) workflows. Key analytical concepts and strategies are explained by reference to selected paradigm studies. Methodological developments that have enabled step change in analytical capability and power to deliver data in biological context are highlighted with reference to specific protocols and original articles. Highlights Current capabilities and strategies are highlighted and include the identification of peptides that contain sites of acetylation and/or methylation, generation of amino acid sequence and information for PTM site assignment; the analysis of protein acetylation and methylation status in different biological states. Stoichiometry and modification dynamics can be determined; the study of intact proteins, peptides, and longer peptides to profile proteoforms; enrichment strategies that aid in in-depth analyses of the methyl- and acetyl-omes; bioinformatics approaches that enable site prediction and provide tools for experimental design for follow-up on selected acetylated and methylated proteins. Proteomic analyses, including MS approaches, have delivered valuable information despite specific technological and bioinformatics challenges. The field is wide and thus specific review articles are signposted in addition to original references." @default.
- W2536832698 created "2016-10-28" @default.
- W2536832698 creator A5075261237 @default.
- W2536832698 date "2016-10-17" @default.
- W2536832698 modified "2023-10-17" @default.
- W2536832698 title "Protein Acetylation and Methylation" @default.
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