Matches in SemOpenAlex for { <https://semopenalex.org/work/W2536906799> ?p ?o ?g. }
Showing items 1 to 62 of
62
with 100 items per page.
- W2536906799 abstract "The MAPK Mpk1 of the Cell Wall Integrity signaling pathway uses a non-catalytic mechanism to activate transcription of cell wall stress-induced genes by acting as a co-transcription factor. Mpk1 serves an additional function in transcription elongation that is also independent of its catalytic activity. This function is mediated by an interaction between Mpk1 and the Paf1 subunit of the Paf1C elongation complex associated with RNA Pol II. The Mpk1-Paf1 interaction blocks recruitment of the Sen1 termination complex to the elongating RNA Pol II, thereby preventing transcriptional attenuation shortly after initiation. Attenuation under non-inducing conditions appears to be a mechanism to minimize basal expression of stress-induced genes. However, under inducing conditions, attenuation must be disabled to allow gene expression. Therefore, Mpk1 serves as an attenuation-relief factor for cell wall stress-induced genes. We found additionally that 10% of yeast protein coding genes are subject to Sen1-mediated attenuation control that is independent of Mpk1 and cell wall stress. This subset is highly enriched for genes induced under various stress conditions, suggesting that transcriptional attenuation is a widespread phenomenon that extends to genes induced in response to a diverse array of stress conditions." @default.
- W2536906799 created "2016-10-28" @default.
- W2536906799 creator A5056383381 @default.
- W2536906799 creator A5058941147 @default.
- W2536906799 date "2012-04-01" @default.
- W2536906799 modified "2023-09-25" @default.
- W2536906799 title "Control of expression of cell wall stress‐induced yeast genes by transcriptional attenuation" @default.
- W2536906799 doi "https://doi.org/10.1096/fasebj.26.1_supplement.232.3" @default.
- W2536906799 hasPublicationYear "2012" @default.
- W2536906799 type Work @default.
- W2536906799 sameAs 2536906799 @default.
- W2536906799 citedByCount "0" @default.
- W2536906799 crossrefType "journal-article" @default.
- W2536906799 hasAuthorship W2536906799A5056383381 @default.
- W2536906799 hasAuthorship W2536906799A5058941147 @default.
- W2536906799 hasConcept C101762097 @default.
- W2536906799 hasConcept C104317684 @default.
- W2536906799 hasConcept C138885662 @default.
- W2536906799 hasConcept C150194340 @default.
- W2536906799 hasConcept C165864922 @default.
- W2536906799 hasConcept C179926584 @default.
- W2536906799 hasConcept C27153228 @default.
- W2536906799 hasConcept C41895202 @default.
- W2536906799 hasConcept C54355233 @default.
- W2536906799 hasConcept C64350747 @default.
- W2536906799 hasConcept C67705224 @default.
- W2536906799 hasConcept C86339819 @default.
- W2536906799 hasConcept C86803240 @default.
- W2536906799 hasConcept C95444343 @default.
- W2536906799 hasConceptScore W2536906799C101762097 @default.
- W2536906799 hasConceptScore W2536906799C104317684 @default.
- W2536906799 hasConceptScore W2536906799C138885662 @default.
- W2536906799 hasConceptScore W2536906799C150194340 @default.
- W2536906799 hasConceptScore W2536906799C165864922 @default.
- W2536906799 hasConceptScore W2536906799C179926584 @default.
- W2536906799 hasConceptScore W2536906799C27153228 @default.
- W2536906799 hasConceptScore W2536906799C41895202 @default.
- W2536906799 hasConceptScore W2536906799C54355233 @default.
- W2536906799 hasConceptScore W2536906799C64350747 @default.
- W2536906799 hasConceptScore W2536906799C67705224 @default.
- W2536906799 hasConceptScore W2536906799C86339819 @default.
- W2536906799 hasConceptScore W2536906799C86803240 @default.
- W2536906799 hasConceptScore W2536906799C95444343 @default.
- W2536906799 hasIssue "S1" @default.
- W2536906799 hasLocation W25369067991 @default.
- W2536906799 hasOpenAccess W2536906799 @default.
- W2536906799 hasPrimaryLocation W25369067991 @default.
- W2536906799 hasRelatedWork W1868173507 @default.
- W2536906799 hasRelatedWork W1930517486 @default.
- W2536906799 hasRelatedWork W2005995134 @default.
- W2536906799 hasRelatedWork W2062378380 @default.
- W2536906799 hasRelatedWork W2074009497 @default.
- W2536906799 hasRelatedWork W2129772929 @default.
- W2536906799 hasRelatedWork W2172226517 @default.
- W2536906799 hasRelatedWork W2516413931 @default.
- W2536906799 hasRelatedWork W4225649985 @default.
- W2536906799 hasRelatedWork W4281611476 @default.
- W2536906799 hasVolume "26" @default.
- W2536906799 isParatext "false" @default.
- W2536906799 isRetracted "false" @default.
- W2536906799 magId "2536906799" @default.
- W2536906799 workType "article" @default.