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- W2536952007 abstract "Regular exercise has systemic beneficial effects including the promotion of brain function. The adaptive response to regular exercise includes the up-regulation of the enzymatic antioxidant system, and modulation of oxidative damage. Reactive oxygen species (ROS) are important regulators of cell signaling and exercise through activity dependent modulation of metabolism and/or direct activation of ROS generating enzymes, thus, modulating the cellular redox state in the brain. ROS are also involved in the self-renewal and differentiation of neuronal stem cells and, as a result, exercise-mediated neurogenesis could be associated with ROS production. Exercise has a powerful effect on the immune system, and readily alters the production of cytokines. Certain cytokines, especially IL-6, IL-1, TNF-a, IL-18 and interferon gamma are actively involved in the modulation of synaptic plasticity and neurogenesis. Cytokines can also contribute to ROS production. ROS- mediated alteration of lipids, protein and DNA could directly affect brain function while exercise modulates the accumulation of oxidative damage. Oxidative alteration of macromolecules, to a moderate degree, can activate signaling processes. Hence, it could be part of the adaptive response to exercise training." @default.
- W2536952007 created "2016-10-28" @default.
- W2536952007 creator A5040707618 @default.
- W2536952007 date "2016-07-08" @default.
- W2536952007 modified "2023-09-24" @default.
- W2536952007 title "EXERCISE AND BRAIN FUNCTION: IS IT REDOX REGULATED?" @default.
- W2536952007 doi "https://doi.org/10.18143/jisanh_v3i2_1441" @default.
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