FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2537163313> ?p ?o ?g. }

• W2537163313 endingPage "3136" @default.
• W2537163313 startingPage "3121" @default.
• W2537163313 abstract "SEE PLUCHINO AND PERUZZOTTI-JAMETTI DOI101093/AWW266 FOR A SCIENTIFIC COMMENTARY ON THIS ARTICLE: Myelin regeneration (remyelination) is a spontaneous process that occurs following central nervous system demyelination. However, for reasons that remain poorly understood, remyelination fails in the progressive phase of multiple sclerosis. Emerging evidence indicates that alternatively activated macrophages in central nervous system lesions are required for oligodendrocyte progenitor differentiation into remyelinating oligodendrocytes. Here, we show that an alternatively activated macrophage secreted enzyme, interleukin-four induced one (IL4I1), is upregulated at the onset of inflammation resolution and remyelination in mouse central nervous system lesions after lysolecithin-induced focal demyelination. Focal demyelination in mice lacking IL4I1 or interleukin 4 receptor alpha (IL4Rα) results in increased proinflammatory macrophage density, remyelination impairment, and axonal injury in central nervous system lesions. Conversely, recombinant IL4I1 administration into central nervous system lesions reduces proinflammatory macrophage density, enhances remyelination, and rescues remyelination impairment in IL4Rα deficient mice. We find that IL4I1 does not directly affect oligodendrocyte differentiation, but modulates inflammation by reducing interferon gamma and IL17 expression in lesioned central nervous system tissues, and in activated T cells from splenocyte cultures. Remarkably, intravenous injection of IL4I1 into mice with experimental autoimmune encephalomyelitis at disease onset significantly reversed disease severity, resulting in recovery from hindlimb paralysis. Analysis of post-mortem tissues reveals reduced axonal dystrophy in spinal cord, and decreased CD4+ T cell populations in spinal cord and spleen tissues. These results indicate that IL4I1 modulates inflammation by regulating T cell expansion, thereby permitting the formation of a favourable environment in the central nervous system tissue for remyelination. Therefore, IL4I1 is a potentially novel therapeutic for promoting central nervous system repair in multiple sclerosis." @default.
• W2537163313 created "2016-10-28" @default.
• W2537163313 creator A5019099973 @default.
• W2537163313 creator A5036063682 @default.
• W2537163313 creator A5039438781 @default.
• W2537163313 creator A5044391130 @default.
• W2537163313 creator A5046576266 @default.
• W2537163313 creator A5057971663 @default.
• W2537163313 creator A5084946323 @default.
• W2537163313 creator A5085255411 @default.
• W2537163313 creator A5091191122 @default.
• W2537163313 date "2016-10-25" @default.
• W2537163313 modified "2023-10-12" @default.
• W2537163313 title "IL4I1 augments CNS remyelination and axonal protection by modulating T cell driven inflammation" @default.
• W2537163313 cites W1164513168 @default.
• W2537163313 cites W1547955534 @default.
• W2537163313 cites W1563760251 @default.
• W2537163313 cites W1937650001 @default.
• W2537163313 cites W1964559049 @default.
• W2537163313 cites W1967561344 @default.
• W2537163313 cites W1973520165 @default.
• W2537163313 cites W1977213877 @default.
• W2537163313 cites W1990047789 @default.
• W2537163313 cites W1990272652 @default.
• W2537163313 cites W2001219925 @default.
• W2537163313 cites W2002433576 @default.
• W2537163313 cites W2002967638 @default.
• W2537163313 cites W2004990490 @default.
• W2537163313 cites W2006178657 @default.
• W2537163313 cites W2007544675 @default.
• W2537163313 cites W2008547188 @default.
• W2537163313 cites W2010453211 @default.
• W2537163313 cites W201993111 @default.
• W2537163313 cites W2021794959 @default.
• W2537163313 cites W2027839244 @default.
• W2537163313 cites W2037425239 @default.
• W2537163313 cites W2037801948 @default.
• W2537163313 cites W2038757125 @default.
• W2537163313 cites W2043200832 @default.
• W2537163313 cites W2048082433 @default.
• W2537163313 cites W2050914686 @default.
• W2537163313 cites W2054275187 @default.
• W2537163313 cites W2055348159 @default.
• W2537163313 cites W2057928734 @default.
• W2537163313 cites W2058500927 @default.
• W2537163313 cites W2058856567 @default.
• W2537163313 cites W2075808173 @default.
• W2537163313 cites W2082062343 @default.
• W2537163313 cites W2091264850 @default.
• W2537163313 cites W2093722536 @default.
• W2537163313 cites W2093738970 @default.
• W2537163313 cites W2121645572 @default.
• W2537163313 cites W2137399557 @default.
• W2537163313 cites W2139297474 @default.
• W2537163313 cites W2142158637 @default.
• W2537163313 cites W2142808413 @default.
• W2537163313 cites W2143235674 @default.
• W2537163313 cites W2145016172 @default.
• W2537163313 cites W2145533845 @default.
• W2537163313 cites W2146358032 @default.
• W2537163313 cites W2147303677 @default.
• W2537163313 cites W2149292237 @default.
• W2537163313 cites W2161456562 @default.
• W2537163313 cites W2162477292 @default.
• W2537163313 cites W2162978315 @default.
• W2537163313 cites W2167626938 @default.
• W2537163313 cites W2168122373 @default.
• W2537163313 cites W2169924875 @default.
• W2537163313 cites W2171561918 @default.
• W2537163313 cites W2172089049 @default.
• W2537163313 cites W2175069001 @default.
• W2537163313 cites W2176522607 @default.
• W2537163313 cites W2218979984 @default.
• W2537163313 cites W2257620318 @default.
• W2537163313 cites W2414412248 @default.
• W2537163313 cites W3091837090 @default.
• W2537163313 cites W4241890711 @default.
• W2537163313 cites W92654312 @default.
• W2537163313 doi "https://doi.org/10.1093/brain/aww254" @default.
• W2537163313 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5382940" @default.
• W2537163313 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27797811" @default.
• W2537163313 hasPublicationYear "2016" @default.
• W2537163313 type Work @default.
• W2537163313 sameAs 2537163313 @default.
• W2537163313 citedByCount "50" @default.
• W2537163313 countsByYear W25371633132016 @default.
• W2537163313 countsByYear W25371633132017 @default.
• W2537163313 countsByYear W25371633132018 @default.
• W2537163313 countsByYear W25371633132019 @default.
• W2537163313 countsByYear W25371633132020 @default.
• W2537163313 countsByYear W25371633132021 @default.
• W2537163313 countsByYear W25371633132022 @default.
• W2537163313 countsByYear W25371633132023 @default.
• W2537163313 crossrefType "journal-article" @default.
• W2537163313 hasAuthorship W2537163313A5019099973 @default.
• W2537163313 hasAuthorship W2537163313A5036063682 @default.
• W2537163313 hasAuthorship W2537163313A5039438781 @default.
• W2537163313 hasAuthorship W2537163313A5044391130 @default.

• next