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• W2537202102 startingPage "2125" @default.
• W2537202102 abstract "Ventilatory acclimatization to hypoxia is associated with an increase in ventilation under conditions of acute hyperoxia (V˙e hyperoxia ) and an increase in acute hypoxic ventilatory response (AHVR). This study compares 48-h exposures to isocapnic hypoxia ( protocol I) with 48-h exposures to poikilocapnic hypoxia ( protocol P) in 10 subjects to assess the importance of hypocapnic alkalosis in generating the changes observed in ventilatory acclimatization to hypoxia. During both hypoxic exposures, end-tidal [Formula: see text] was maintained at 60 Torr, with end-tidal [Formula: see text] held at the subject’s prehypoxic level ( protocol I) or uncontrolled ( protocol P).V˙e hyperoxia and AHVR were assessed regularly throughout the exposures.V˙e hyperoxia ( P < 0.001, ANOVA) and AHVR ( P < 0.001) increased during the hypoxic exposures, with no significant differences between protocols I and P. The increase inV˙e hyperoxia was associated with an increase in slope of the ventilation-end-tidal [Formula: see text] response ( P < 0.001) with no significant change in intercept. These results suggest that changes in respiratory control early in ventilatory acclimatization to hypoxia result from the effects of hypoxia per se and not the alkalosis normally accompanying hypoxia." @default.
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• W2537202102 date "1998-12-01" @default.
• W2537202102 modified "2023-10-18" @default.
• W2537202102 title "Changes in respiratory control during and after 48 h of isocapnic and poikilocapnic hypoxia in humans" @default.
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• W2537202102 doi "https://doi.org/10.1152/jappl.1998.85.6.2125" @default.
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