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• W2537222080 abstract "The initial structure activity relationships around an isoindoline uHTS hit will be described. Information gleaned from ligand co-crystal structures allowed for rapid refinements in both MARK potency and kinase selectivity. These efforts allowed for the identification of a compound with properties suitable for use as an in vitro tool compound for validation studies on MARK as a viable target for Alzheimer’s disease.Download : Download high-res image (27KB)Download : Download full-size image" @default.
• W2537222080 created "2016-10-28" @default.
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• W2537222080 date "2017-01-01" @default.
• W2537222080 modified "2023-10-18" @default.
• W2537222080 title "Structure guided design of a series of selective pyrrolopyrimidinone MARK inhibitors" @default.
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• W2537222080 doi "https://doi.org/10.1016/j.bmcl.2016.08.068" @default.
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